Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG40020)
Regulator Name CircRPPH1 (circRNA)
Synonyms
CircRPPH1
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Gene Name CircRPPH1
Regulator Type circRNA
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
CircRPPH1 can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Cystine/glutamate transporter (SLC7A11) [Driver; Suppressor]
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Target for Ferroptosis Suppressor
Responsed Disease Gastric cancer ICD-11: 2B72
 Disease Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 MKN45 cells Gastric adenocarcinoma Homo sapiens CVCL_0434
AGS cells Gastric adenocarcinoma Homo sapiens CVCL_0139
Hs746T cells Gastric adenocarcinoma Homo sapiens CVCL_0333
NCI-N87 cells Gastric tubular adenocarcinoma Homo sapiens CVCL_1603
HGC-27 cells Gastric carcinoma Homo sapiens CVCL_1279
Response regulation circRPPH1 promoted the stemness of gastric cancer cells dependent on the miR-375/SLC7A11. This study provides a potential target for gastric cancer progression based on the circRPPH1/miR-375/SLC7A11 regulatory axis.
Gastric cancer [ICD-11: 2B72]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator CircRPPH1 (circRNA) circRNA
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 MKN45 cells Gastric adenocarcinoma Homo sapiens CVCL_0434
AGS cells Gastric adenocarcinoma Homo sapiens CVCL_0139
Hs746T cells Gastric adenocarcinoma Homo sapiens CVCL_0333
NCI-N87 cells Gastric tubular adenocarcinoma Homo sapiens CVCL_1603
HGC-27 cells Gastric carcinoma Homo sapiens CVCL_1279
Response regulation circRPPH1 promoted the stemness of gastric cancer cells dependent on the miR-375/SLC7A11. This study provides a potential target for gastric cancer progression based on the circRPPH1/miR-375/SLC7A11 regulatory axis.
References
Ref 1 CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR-375/SLC7A11 axis. Environ Toxicol. 2023 Jan;38(1):115-125. doi: 10.1002/tox.23668. Epub 2022 Oct 3.