Ferroptosis Regulator Information
General Information of the Ferroptosis Regulator (ID: REG40012)
| Regulator Name | CircPVT1 (circRNA) | ||||
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| Synonyms |
CircPVT1
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| Gene Name | CircPVT1 | ||||
| Regulator Type | circRNA | ||||
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
CircPVT1
can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Phospholipid hydroperoxide glutathione peroxidase (GPX4) [Suppressor]
| In total 1 item(s) under this target | |||||
| Experiment 1 Reporting the Ferroptosis Target of This Regulator | [1] | ||||
| Target for Ferroptosis | Suppressor | ||||
| Responsed Disease | Oesophageal cancer | ICD-11: 2B70 | |||
| Pathway Response | Wnt signaling pathway | hsa04310 | |||
| Fatty acid metabolism | hsa01212 | ||||
| Cell Process | Cell ferroptosis | ||||
| Cell proliferation | |||||
| Cell invasion | |||||
In Vitro Model |
EC9706 cells | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_E307 | |
| KYSE-70 cells | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1356 | ||
| hEECs (Human esophageal epithelial cells) | |||||
| In Vivo Model |
BALB/c nude male mice of 4 weeks old were purchased from the Model Animal Research Center of Nanjing University (Nanjing, China). After one week of adaptive feeding, EC9706 cells (3 x 106) stably expressing sh-NC and sh-circPVT1, sh-NC + 5-FU and sh-circPVT1 + 5-FU were subcutaneously were injected into the right flank of the nude mice in a serum-free DMEM medium.
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| Response regulation | CircPVT1 regulated the chemosensitivity of esophageal squamous cell carcinoma cells through ROS and Wnt/-catenin pathwaysviamiR-30a-5p/FZD3. Knockdown of circPVT1 promoted chemosensitivity in ESCC by increasing ferroptosis via downregulating GPX4 and SLC7A11. | ||||
Cystine/glutamate transporter (SLC7A11) [Driver; Suppressor]
| In total 1 item(s) under this target | |||||
| Experiment 1 Reporting the Ferroptosis Target of This Regulator | [1] | ||||
| Target for Ferroptosis | Suppressor | ||||
| Responsed Disease | Oesophageal cancer | ICD-11: 2B70 | |||
| Pathway Response | Wnt signaling pathway | hsa04310 | |||
| Fatty acid metabolism | hsa01212 | ||||
| Cell Process | Cell ferroptosis | ||||
| Cell proliferation | |||||
| Cell invasion | |||||
In Vitro Model |
EC9706 cells | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_E307 | |
| KYSE-70 cells | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1356 | ||
| hEECs (Human esophageal epithelial cells) | |||||
| In Vivo Model |
BALB/c nude male mice of 4 weeks old were purchased from the Model Animal Research Center of Nanjing University (Nanjing, China). After one week of adaptive feeding, EC9706 cells (3 x 106) stably expressing sh-NC and sh-circPVT1, sh-NC + 5-FU and sh-circPVT1 + 5-FU were subcutaneously were injected into the right flank of the nude mice in a serum-free DMEM medium.
Click to Show/Hide
|
||||
| Response regulation | CircPVT1 regulated the chemosensitivity of esophageal squamous cell carcinoma cells through ROS and Wnt/-catenin pathwaysviamiR-30a-5p/FZD3. Knockdown of circPVT1 promoted chemosensitivity in ESCC by increasing ferroptosis via downregulating GPX4 and SLC7A11. | ||||
Oesophageal cancer [ICD-11: 2B70]
| In total 2 item(s) under this disease | |||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response | [1] | ||||
| Target Regulator | CircPVT1 (circRNA) | circRNA | |||
| Pathway Response | Wnt signaling pathway | hsa04310 | |||
| Fatty acid metabolism | hsa01212 | ||||
| Cell Process | Cell ferroptosis | ||||
| Cell proliferation | |||||
| Cell invasion | |||||
In Vitro Model |
EC9706 cells | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_E307 | |
| KYSE-70 cells | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1356 | ||
| hEECs (Human esophageal epithelial cells) | |||||
| In Vivo Model |
BALB/c nude male mice of 4 weeks old were purchased from the Model Animal Research Center of Nanjing University (Nanjing, China). After one week of adaptive feeding, EC9706 cells (3 x 106) stably expressing sh-NC and sh-circPVT1, sh-NC + 5-FU and sh-circPVT1 + 5-FU were subcutaneously were injected into the right flank of the nude mice in a serum-free DMEM medium.
Click to Show/Hide
|
||||
| Response regulation | CircPVT1 regulated the chemosensitivity of esophageal squamous cell carcinoma cells through ROS and Wnt/-catenin pathwaysviamiR-30a-5p/FZD3. Knockdown of circPVT1 promoted chemosensitivity in ESCC by increasing ferroptosis via downregulating GPX4 and SLC7A11. | ||||
| Experiment 2 Reporting the Ferroptosis-centered Disease Response | [1] | ||||
| Target Regulator | CircPVT1 (circRNA) | circRNA | |||
| Pathway Response | Wnt signaling pathway | hsa04310 | |||
| Fatty acid metabolism | hsa01212 | ||||
| Cell Process | Cell ferroptosis | ||||
| Cell proliferation | |||||
| Cell invasion | |||||
In Vitro Model |
EC9706 cells | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_E307 | |
| KYSE-70 cells | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1356 | ||
| hEECs (Human esophageal epithelial cells) | |||||
| In Vivo Model |
BALB/c nude male mice of 4 weeks old were purchased from the Model Animal Research Center of Nanjing University (Nanjing, China). After one week of adaptive feeding, EC9706 cells (3 x 106) stably expressing sh-NC and sh-circPVT1, sh-NC + 5-FU and sh-circPVT1 + 5-FU were subcutaneously were injected into the right flank of the nude mice in a serum-free DMEM medium.
Click to Show/Hide
|
||||
| Response regulation | CircPVT1 regulated the chemosensitivity of esophageal squamous cell carcinoma cells through ROS and Wnt/-catenin pathwaysviamiR-30a-5p/FZD3. Knockdown of circPVT1 promoted chemosensitivity in ESCC by increasing ferroptosis via downregulating GPX4 and SLC7A11. | ||||