Ferroptosis Regulator Information
General Information of the Ferroptosis Regulator (ID: REG30055)
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
Lnc-TC
can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Phospholipid hydroperoxide glutathione peroxidase (GPX4) [Suppressor]
| In total 1 item(s) under this target | ||||
| Experiment 1 Reporting the Ferroptosis Target of This Regulator | [1] | |||
| Target for Ferroptosis | Suppressor | |||
| Responsed Disease | Hematotoxicity | ICD-11: 3A70 | ||
| Pathway Response | Ferroptosis | hsa04216 | ||
| Cell Process | Cell ferroptosis | |||
In Vitro Model |
AHH-1 cells | Normal | Homo sapiens | CVCL_3640 |
| Response regulation | Lnc-TC/miR-142-5p/CUL4B signaling axis promoted cell ferroptosis to participate in benzene hematotoxicity, and was a potential biomarker for risk screening and health surveillance of benzene-exposed workers. The expression of GPX4 was negatively correlated with both Lnc-TC and CUL4B. | |||
Hematotoxicity [ICD-11: 3A70]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response | [1] | |||
| Target Regulator | Lnc-TC (IncRNA) | lncRNA | ||
| Pathway Response | Ferroptosis | hsa04216 | ||
| Cell Process | Cell ferroptosis | |||
In Vitro Model |
AHH-1 cells | Normal | Homo sapiens | CVCL_3640 |
| Response regulation | Lnc-TC/miR-142-5p/CUL4B signaling axis promoted cell ferroptosis to participate in benzene hematotoxicity, and was a potential biomarker for risk screening and health surveillance of benzene-exposed workers. The expression of GPX4 was negatively correlated with both Lnc-TC and CUL4B. | |||