Ferroptosis-centered Disease Response Information

General Information of the Disease (ID: DIS00053)
Name
Hematotoxicity
ICD
ICD-11: 3A70
Full List of Target(s) of This Ferroptosis-centered Disease
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
 Target Info 
In total 3 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Benzene hematotoxicity [ICD-11: 3A70]
Responsed Regulator Lnc-TC (IncRNA) Driver
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model AHH-1 cells Normal Homo sapiens CVCL_3640
Response regulation Lnc-TC/miR-142-5p/CUL4B signaling axis promoted cell ferroptosis to participate in benzene hematotoxicity, and was a potential biomarker for risk screening and health surveillance of benzene-exposed workers. The expression of GPX4 was negatively correlated with both Lnc-TC and CUL4B.
Experiment 2 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Benzene hematotoxicity [ICD-11: 3A70]
Responsed Regulator hsa-miR-142-5p (miRNA) Suppressor
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model AHH-1 cells Normal Homo sapiens CVCL_3640
Response regulation Lnc-TC/ miR-142-5p/CUL4B signaling axis promoted cell ferroptosis to participate in benzene hematotoxicity, and was a potential biomarker for risk screening and health surveillance of benzene-exposed workers. The expression of GPX4 was negatively correlated with both Lnc-TC and CUL4B.
Experiment 3 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Benzene hematotoxicity [ICD-11: 3A70]
Responsed Regulator Cullin-4B (CUL4B) Driver
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model AHH-1 cells Normal Homo sapiens CVCL_3640
Response regulation Lnc-TC/miR-142-5p/ CUL4B signaling axis promoted cell ferroptosis to participate in benzene hematotoxicity, and was a potential biomarker for risk screening and health surveillance of benzene-exposed workers. The expression of GPX4 was negatively correlated with both Lnc-TC and CUL4B.
References
Ref 1 Lnc-TC/miR-142-5p/CUL4B signaling axis promoted cell ferroptosis to participate in benzene hematotoxicity. Life Sci. 2022 Dec 1;310:121111. doi: 10.1016/j.lfs.2022.121111. Epub 2022 Oct 20.