Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG30027)
Regulator Name OIP5-AS1 (IncRNA)
Synonyms
OIP5-AS1
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Gene Name OIP5-AS1
Gene ID 729082
Regulator Type lncRNA
Ensembl ID ENSG00000247556
HGNC ID
HGNC:43563
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
OIP5-AS1 can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
Browse Target
Browse Disease
Phospholipid hydroperoxide glutathione peroxidase (GPX4) [Suppressor]
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Target for Ferroptosis Suppressor
Responsed Disease Oesophageal cancer ICD-11: 2B70
 Disease Info 
Pathway Response Ferroptosis hsa04216
Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model
 Eca-109 cells Esophageal squamous cell carcinoma Homo sapiens CVCL_6898
TE-13 cells Esophageal squamous cell carcinoma Homo sapiens CVCL_4463
TE-1 cells Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
T.Tn cells Esophageal squamous cell carcinoma Homo sapiens CVCL_3175
hOECs (Normal oesophageal epithelial cells)
Response regulation OIP5-AS1 inhibition significantly inhibited Oesophageal cancer (EC) cell viability and proliferation, induced ferroptosis, and downregulated GPX4 levels, while GPX4 reversed these effects.
Cystine/glutamate transporter (SLC7A11) [Driver; Suppressor]
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [2]
Target for Ferroptosis Suppressor
Responsed Disease Prostate cancer ICD-11: 2C82
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell proliferation
Cell invasion
In Vitro Model
 PC-3 cells Prostate carcinoma Homo sapiens CVCL_0035
DU145 cells Prostate carcinoma Homo sapiens CVCL_0105
In Vivo Model
A total of 2 x 106 PC3 and PC3/Cd cells were subcutaneously injected into the right flanks of 4-week-old male Balb/c nude mice. Tumor burdens were closely monitored by tumor volumes. When the largest tumors reached a size of 1.0 cm3, all mice were sacrificed due to ethical considerations. Moreover, the final tumor weight was also recorded.

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Response regulation OIP5-AS1 served as an endogenous sponge of miR-128-3p to regulate the expression of SLC7A11, a surrogate marker of ferroptosis. Moreover, miR-128-3p decreased cell viability by enhancing ferroptosis. Taken together, lncRNA OIP5-AS1 promotes prostate cancer progression and ferroptosis resistance through miR-128-3p/SLC7A11 signaling.
Oesophageal cancer [ICD-11: 2B70]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator OIP5-AS1 (IncRNA) lncRNA
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model
 Eca-109 cells Esophageal squamous cell carcinoma Homo sapiens CVCL_6898
TE-13 cells Esophageal squamous cell carcinoma Homo sapiens CVCL_4463
TE-1 cells Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
T.Tn cells Esophageal squamous cell carcinoma Homo sapiens CVCL_3175
hOECs (Normal oesophageal epithelial cells)
Response regulation OIP5-AS1 inhibition significantly inhibited Oesophageal cancer (EC) cell viability and proliferation, induced ferroptosis, and downregulated GPX4 levels, while GPX4 reversed these effects.
Prostate cancer [ICD-11: 2C82]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [2]
Target Regulator OIP5-AS1 (IncRNA) lncRNA
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell proliferation
Cell invasion
In Vitro Model
 PC-3 cells Prostate carcinoma Homo sapiens CVCL_0035
DU145 cells Prostate carcinoma Homo sapiens CVCL_0105
In Vivo Model
A total of 2 x 106 PC3 and PC3/Cd cells were subcutaneously injected into the right flanks of 4-week-old male Balb/c nude mice. Tumor burdens were closely monitored by tumor volumes. When the largest tumors reached a size of 1.0 cm3, all mice were sacrificed due to ethical considerations. Moreover, the final tumor weight was also recorded.

    Click to Show/Hide
Response regulation OIP5-AS1 served as an endogenous sponge of miR-128-3p to regulate the expression of SLC7A11, a surrogate marker of ferroptosis. Moreover, miR-128-3p decreased cell viability by enhancing ferroptosis. Taken together, lncRNA OIP5-AS1 promotes prostate cancer progression and ferroptosis resistance through miR-128-3p/SLC7A11 signaling.
References
Ref 1 LncRNA OIP5-AS1 Knockdown Facilitated the Ferroptosis and Immune Evasion by Modulating the GPX4 in Oesophageal Carcinoma. Comput Math Methods Med. 2022 Jul 15;2022:8103198. doi: 10.1155/2022/8103198. eCollection 2022.
Ref 2 LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling. Ecotoxicol Environ Saf. 2021 Sep 1;220:112376. doi: 10.1016/j.ecoenv.2021.112376. Epub 2021 May 26.