Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG30011)
Regulator Name HOTAIR (IncRNA)
Synonyms
HOTAIR
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Gene Name HOTAIR
Gene ID 100124700
Regulator Type lncRNA
Ensembl ID ENSG00000228630
HGNC ID
HGNC:33510
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
HOTAIR can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Long-chain-fatty-acid--CoA ligase 4 (ACSL4) [Driver]
 Target Info 
In total 2 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Target for Ferroptosis Driver
Responsed Disease Intracerebral hemorrhage ICD-11: 8B00
 Disease Info 
Responsed Drug Paeonol Investigative
 Drug Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 HT22 cells Normal Mus musculus CVCL_0321
In Vivo Model
C57BL/6 mice (aged 8-10 weeks, Vital River, Beijing, China) were housed in SPF conditions. The animal study was performed according to the National Institutes of Health Guide and approved by the Ethics Committees of Affiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan University.

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Response regulation Paeonol (PAN) inhibits the progression of intracerebral haemorrhage via the HOTAIR/UPF1/ACSL4 signalling pathway. Thus, PAN could act as a new agent for the treatment of ferroptosis in intracerebral haemorrhage.
Experiment 2 Reporting the Ferroptosis Target of This Regulator [1]
Target for Ferroptosis Driver
Responsed Disease Intracerebral hemorrhage ICD-11: 8B00
 Disease Info 
Responsed Drug Paeonol Investigative
 Drug Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 HT22 cells Normal Mus musculus CVCL_0321
In Vivo Model
C57BL/6 mice (aged 8-10 weeks, Vital River, Beijing, China) were housed in SPF conditions. The animal study was performed according to the National Institutes of Health Guide and approved by the Ethics Committees of Affiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan University.

    Click to Show/Hide
Response regulation Paeonol (PAN) inhibits the progression of intracerebral haemorrhage via the HOTAIR/ UPF1/ACSL4 signalling pathway. Thus, PAN could act as a new agent for the treatment of ferroptosis in intracerebral haemorrhage.
Intracerebral hemorrhage [ICD-11: 8B00]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator HOTAIR (IncRNA) lncRNA
 Regulator Info 
Responsed Drug Paeonol Investigative
 Drug Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 HT22 cells Normal Mus musculus CVCL_0321
In Vivo Model
C57BL/6 mice (aged 8-10 weeks, Vital River, Beijing, China) were housed in SPF conditions. The animal study was performed according to the National Institutes of Health Guide and approved by the Ethics Committees of Affiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan University.

    Click to Show/Hide
Response regulation Paeonol (PAN) inhibits the progression of intracerebral haemorrhage via the HOTAIR/UPF1/ACSL4 signalling pathway. Thus, PAN could act as a new agent for the treatment of ferroptosis in intracerebral haemorrhage.
Experiment 2 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator HOTAIR (IncRNA) lncRNA
 Regulator Info 
Responsed Drug Paeonol Investigative
 Drug Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 HT22 cells Normal Mus musculus CVCL_0321
In Vivo Model
C57BL/6 mice (aged 8-10 weeks, Vital River, Beijing, China) were housed in SPF conditions. The animal study was performed according to the National Institutes of Health Guide and approved by the Ethics Committees of Affiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan University.

    Click to Show/Hide
Response regulation Paeonol (PAN) inhibits the progression of intracerebral haemorrhage via the HOTAIR/ UPF1/ACSL4 signalling pathway. Thus, PAN could act as a new agent for the treatment of ferroptosis in intracerebral haemorrhage.
Paeonol [Investigative]
 Drug Info 
In total 2 item(s) under this drug
Experiment 1 Reporting the Ferroptosis-centered Drug Response [1]
Drug for Ferroptosis Suppressor
Response Target Long-chain-fatty-acid--CoA ligase 4 (ACSL4) Driver
 Target Info 
Responsed Disease Intracerebral hemorrhage ICD-11: 8B00
 Disease Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 HT22 cells Normal Mus musculus CVCL_0321
In Vivo Model
C57BL/6 mice (aged 8-10 weeks, Vital River, Beijing, China) were housed in SPF conditions. The animal study was performed according to the National Institutes of Health Guide and approved by the Ethics Committees of Affiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan University.

    Click to Show/Hide
Response regulation Paeonol (PAN) inhibits the progression of intracerebral haemorrhage via the HOTAIR/UPF1/ACSL4 signalling pathway. Thus, PAN could act as a new agent for the treatment of ferroptosis in intracerebral haemorrhage.
Experiment 2 Reporting the Ferroptosis-centered Drug Response [1]
Drug for Ferroptosis Suppressor
Response Target Long-chain-fatty-acid--CoA ligase 4 (ACSL4) Driver
 Target Info 
Responsed Disease Intracerebral hemorrhage ICD-11: 8B00
 Disease Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 HT22 cells Normal Mus musculus CVCL_0321
In Vivo Model
C57BL/6 mice (aged 8-10 weeks, Vital River, Beijing, China) were housed in SPF conditions. The animal study was performed according to the National Institutes of Health Guide and approved by the Ethics Committees of Affiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan University.

    Click to Show/Hide
Response regulation Paeonol (PAN) inhibits the progression of intracerebral haemorrhage via the HOTAIR/ UPF1/ACSL4 signalling pathway. Thus, PAN could act as a new agent for the treatment of ferroptosis in intracerebral haemorrhage.
References
Ref 1 Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis. ASN Neuro. 2021 Jan-Dec;13:17590914211010647. doi: 10.1177/17590914211010647.