Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0104)
Name
Paeonol
Synonyms
PAEONOL; 552-41-0; 2'-Hydroxy-4'-methoxyacetophenone; 1-(2-Hydroxy-4-methoxyphenyl)ethanone; Peonol; 2-Hydroxy-4-methoxyacetophenone; Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-; 1-(2-hydroxy-4-methoxyphenyl)ethan-1-one; 4-O-Methylresacetophenone; Resacetophenone-4-methyl ether; 4'-Methoxy-2'-hydroxyacetophenone; MFCD00008730; Paeonal; Acetophenone, 2'-hydroxy-4'-methoxy-; 2-acetyl-5-methoxyphenol; Resacetophenone, 4-O-methyl ester; EINECS 209-012-2; NSC 401442; UNII-3R834EPI82; BRN 1282794; 1-(2-hydroxy-4-methoxy-phenyl)ethanone; AI3-10581; 3R834EPI82; NSC-401442; RESACETOPHENONE 4-O-METHYL ETHER; CHEMBL1079227; CHEBI:69581; 4-08-00-01793 (Beilstein Handbook Reference); 1-(2-hydroxy-4-methoxy-phenyl)-ethanone; 1-(4-METHOXY-2-HYDROXYPHENYL)ETHANONE; 2-HYDROXY-4-METHOXYPHENYL METHYL KETONE; 2-HYDROXY-4-METHOXYACETOPHENONE (4,4,4-D3); Paeonol (Peonol); PAEONOL [INCI]; 1-[2-hydroxy-4-(methyloxy)phenyl]ethanone; Spectrum2_001981; Spectrum3_001686; PAEONOL [WHO-DD]; 2-Acetyl-5-methoxy-phenol; CBiol_000986; BSPBio_003212; MLS006011902; SPECTRUM1601021; SPBio_002161; SCHEMBL1449478; DTXSID1022059; KBio3_002432; 4-methoxy 2-hydroxy acetophenone; HMS3656E07; HMS3884J13; 2`-Hydroxy-4`-methoxyacetophenone; HY-N0159; BBL012127; BDBM50310718; CCG-39471; ICCB4_000282; NSC401442; s2339; STK078097; AKOS000119646; AC-7982; SDCCGMLS-0066845.P001; 1-(2-hydroxy-4-methoxyphenyl)-ethanone; NCGC00095977-01; NCGC00095977-02; NCGC00095977-03; 2'-Hydroxy-4'-methoxyacetophenone, 99%; AS-15489; SMR000112386; SY013508; 1-(2-Hydroxy-4-methoxyphenyl)ethanone #; 1-(4-Methoxy-2-hydroxy-phenyl)-ethanone; 1-(2-hydroxy-4-methoxyphenyl)ethane-1-one; AM20040702; FT-0602529; FT-0618875; H0789; quinuclidin-3-one oxime hydrochloride;Paeonol; SW219250-1; EN300-17920; A830551; Acetophenone, 2'-hydroxy-4'-methoxy-(7CI,8CI); SR-05000002397; Q-100626; Q7124105; SR-05000002397-1; BRD-K94239562-001-02-2; BRD-K94239562-001-03-0; Z57101020; 2 inverted exclamation mark -Hydroxy-4 inverted exclamation mark -methoxyacetophenone; 2 inverted exclamation marka-Hydroxy-4 inverted exclamation marka-methoxyacetophenone; InChI=1/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H

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Structure
Formula
C9H10O3
IUPAC Name
1-(2-hydroxy-4-methoxyphenyl)ethanone
Canonical SMILES
CC(=O)C1=C(C=C(C=C1)OC)O
InChI
InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3
InChIKey
UILPJVPSNHJFIK-UHFFFAOYSA-N
PubChem CID
11092
Full List of Ferroptosis Target Related to This Drug
Long-chain-fatty-acid--CoA ligase 4 (ACSL4)
 Target Info 
In total 2 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Driver
Responsed Disease Intracerebral hemorrhage ICD-11: 8B00
 Disease Info 
Responsed Regulator HOTAIR (IncRNA) Driver
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model HT22 cells Normal Mus musculus CVCL_0321
In Vivo Model
C57BL/6 mice (aged 8-10 weeks, Vital River, Beijing, China) were housed in SPF conditions. The animal study was performed according to the National Institutes of Health Guide and approved by the Ethics Committees of Affiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan University.

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Response regulation Paeonol (PAN) inhibits the progression of intracerebral haemorrhage via the HOTAIR/UPF1/ACSL4 signalling pathway. Thus, PAN could act as a new agent for the treatment of ferroptosis in intracerebral haemorrhage.
Experiment 2 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Driver
Responsed Disease Intracerebral hemorrhage ICD-11: 8B00
 Disease Info 
Responsed Regulator HOTAIR (IncRNA) Suppressor
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model HT22 cells Normal Mus musculus CVCL_0321
In Vivo Model
C57BL/6 mice (aged 8-10 weeks, Vital River, Beijing, China) were housed in SPF conditions. The animal study was performed according to the National Institutes of Health Guide and approved by the Ethics Committees of Affiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan University.

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Response regulation Paeonol (PAN) inhibits the progression of intracerebral haemorrhage via the HOTAIR/ UPF1/ACSL4 signalling pathway. Thus, PAN could act as a new agent for the treatment of ferroptosis in intracerebral haemorrhage.
References
Ref 1 Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis. ASN Neuro. 2021 Jan-Dec;13:17590914211010647. doi: 10.1177/17590914211010647.