Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG30008)
Regulator Name MEG8 (IncRNA)
Synonyms
MEG8
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Gene Name MEG8
Gene ID 79104
Regulator Type lncRNA
Ensembl ID ENSG00000225746
HGNC ID
HGNC:14574
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
MEG8 can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
Browse Target
Browse Disease
Cystine/glutamate transporter (SLC7A11) [Driver; Suppressor]
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Target for Ferroptosis Suppressor
Responsed Disease Hemangioma ICD-11: 2E81
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Notch signaling pathway hsa04330
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model
 hHemECs (Human hemangioma endothelial cells)
Response regulation Knockdown of long non-coding RNA MEG8 inhibited the proliferation and induced the ferroptosis of hemangioma endothelial cells by regulating miR-497-5p/NOTCH2 axis. Importantly, silencing MEG8 significantly decreased the expressions of SLC7A11 and GPX4 both in mRNA and protein level and had no effect on the level of AIFM2.
Hemangioma [ICD-11: 2E81]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator MEG8 (IncRNA) lncRNA
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Notch signaling pathway hsa04330
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model
 hHemECs (Human hemangioma endothelial cells)
Response regulation Knockdown of long non-coding RNA MEG8 inhibited the proliferation and induced the ferroptosis of hemangioma endothelial cells by regulating miR-497-5p/NOTCH2 axis. Importantly, silencing MEG8 significantly decreased the expressions of SLC7A11 and GPX4 both in mRNA and protein level and had no effect on the level of AIFM2.
References
Ref 1 Silencing long non-coding RNA MEG8 inhibits the proliferation and induces the ferroptosis of hemangioma endothelial cells by regulating miR-497-5p/NOTCH2 axis. Biochem Biophys Res Commun. 2021 Jun 4;556:72-78. doi: 10.1016/j.bbrc.2021.03.132. Epub 2021 Apr 8.