Ferroptosis-centered Disease Response Information

General Information of the Disease (ID: DIS00051)
Name
Hemangioma
ICD
ICD-11: 2E81
Full List of Target(s) of This Ferroptosis-centered Disease
Cystine/glutamate transporter (SLC7A11)
 Target Info 
In total 3 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Hemangioma [ICD-11: 2E81]
Responsed Regulator hsa-miR-497-5p (miRNA) Driver
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Notch signaling pathway hsa04330
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model hHemECs (Human hemangioma endothelial cells)
Response regulation Knockdown of long non-coding RNA MEG8 inhibited the proliferation and induced the ferroptosis of hemangioma endothelial cells by regulating miR-497-5p/NOTCH2 axis. Importantly, silencing MEG8 significantly decreased the expressions of SLC7A11 and GPX4 both in mRNA and protein level and had no effect on the level of AIFM2.
Experiment 2 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Hemangioma [ICD-11: 2E81]
Responsed Regulator Neurogenic locus notch homolog protein 2 (NOTCH2) Suppressor
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Notch signaling pathway hsa04330
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model hHemECs (Human hemangioma endothelial cells)
Response regulation Knockdown of long non-coding RNA MEG8 inhibited the proliferation and induced the ferroptosis of hemangioma endothelial cells by regulating miR-497-5p/ NOTCH2 axis. Importantly, silencing MEG8 significantly decreased the expressions of SLC7A11 and GPX4 both in mRNA and protein level and had no effect on the level of AIFM2.
Experiment 3 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Hemangioma [ICD-11: 2E81]
Responsed Regulator MEG8 (IncRNA) Suppressor
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Notch signaling pathway hsa04330
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model hHemECs (Human hemangioma endothelial cells)
Response regulation Knockdown of long non-coding RNA MEG8 inhibited the proliferation and induced the ferroptosis of hemangioma endothelial cells by regulating miR-497-5p/NOTCH2 axis. Importantly, silencing MEG8 significantly decreased the expressions of SLC7A11 and GPX4 both in mRNA and protein level and had no effect on the level of AIFM2.
References
Ref 1 Silencing long non-coding RNA MEG8 inhibits the proliferation and induces the ferroptosis of hemangioma endothelial cells by regulating miR-497-5p/NOTCH2 axis. Biochem Biophys Res Commun. 2021 Jun 4;556:72-78. doi: 10.1016/j.bbrc.2021.03.132. Epub 2021 Apr 8.