Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0114)
Name
Sodium iodate
Synonyms
SODIUM IODATE; 7681-55-2; sodium;iodate; Iodic acid, sodium salt; U558PCS5Z9; Natriumjodat; Iodic acid (HIO3), sodium salt (1:1); Natriumjodat [German]; Sodium iodate (NaIO3) pentahydrate; HSDB 749; EINECS 231-672-5; NSC 77387; UNII-U558PCS5Z9; IODIC ACID, SODIUM SALT, PENTAHYDRATE; MFCD00003533; Sodium iodate, >=99%; Na I O3; SODIUM IODATE [MI]; SODIUM IODATE [HSDB]; SODIUM IODATE [INCI]; Sodium iodate, >=99.5%; SODIUM IODATE [WHO-DD]; CHEBI:81708; DTXSID90858754; WTCBONOLBHEDIL-UHFFFAOYSA-M; AKOS015951016; 17250-90-7; Sodium iodate, BioUltra, >=99.5% (RT); C18366; Sodium iodate, puriss. p.a., >=99.5% (RT); Q411126

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Structure
3D MOL
2D MOL
Formula
INaO3
IUPAC Name
sodium;iodate
Canonical SMILES
[O-]I(=O)=O.[Na+]
InChI
InChI=1S/HIO3.Na/c2-1(3)4;/h(H,2,3,4);/q;+1/p-1
InChIKey
WTCBONOLBHEDIL-UHFFFAOYSA-M
PubChem CID
23675764
Full List of Ferroptosis Target Related to This Drug
Heme oxygenase 1 (HMOX1)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Driver/Suppressor
Responsed Disease Age-related macular degeneration ICD-11: 9B75
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model ARPE-19 cells Normal Homo sapiens CVCL_0145
In Vivo Model
In this study, sixteen-week-old male C57BL/6 mice were used and housed in a standard laboratory environment. Forin vivostudies, left eyes were pretreated with a single intravitreal injection of DMSO (1 uL) or 1X PBS (1 uL), and right eyes were pretreated with Fer-1 (30 uM, a single intravitreal injection, 1 uL), DFO (100 uM, a single intravitreal injection, 1 uL), or ZnPP (50 mg/kg, intraperitoneal injection once a week). 15 min later, injection of NaIO3(35 mg/kg, a single injectionviatail vein), or 1X PBS (a single injectionviatail vein, 75 uL) has been performed. After 2 weeks, mice were used for subsequent experiments.

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Response regulation Sodium iodate-induced oxidative stress model has been identified to be heme oxygenase-1 (HO-1)-regulated ferroptosis, which is controlled by the Nrf2-SLC7A11-HO-1 hierarchy. These findings highlight that targeting HO-1-mediated RPE ferroptosis could serve as an effectively retinal-protective strategy for retinal degenerative diseases prevention, including age-related macular degeneration (AMD).
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [2]
Responsed Disease Peripheral retinal degeneration ICD-11: 9B78
 Disease Info 
Pathway Response Ferroptosis hsa04216
Glutathione metabolism hsa00480
Cell Process Cell ferroptosis
In Vitro Model ARPE-19 cells Normal Homo sapiens CVCL_0145
HT-29 cells Colon adenocarcinoma Homo sapiens CVCL_0320
SH-SY5Y cells Neuroblastoma Homo sapiens CVCL_0019
Jurkat cells T acute lymphoblastic leukemia Homo sapiens CVCL_0065
Response regulation Sodium iodate (SI) is a widely used oxidant for generating retinal degeneration models by inducing the death of retinal pigment epithelium (RPE) cells. SI depletes GSH, increases ROS, releases labile iron, and boosts lipid damage, which in turn results in ferroptosis in ARPE-19 cells.
References
Ref 1 HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration. Redox Biol. 2021 Jul;43:101971. doi: 10.1016/j.redox.2021.101971. Epub 2021 Apr 17.
Ref 2 Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells. Cell Death Dis. 2021 Mar 3;12(3):230. doi: 10.1038/s41419-021-03520-2.