Ferroptosis-centered Disease Response Information

General Information of the Disease (ID: DIS00089)
Name
Peripheral retinal degeneration
ICD
ICD-11: 9B78
Full List of Target(s) of This Ferroptosis-centered Disease
Unspecific Target
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Responsed Disease Peripheral retinal degeneration [ICD-11: 9B78]
Responsed Drug Sodium iodate Investigative
 Drug Info 
Pathway Response Ferroptosis hsa04216
Glutathione metabolism hsa00480
Cell Process Cell ferroptosis
In Vitro Model ARPE-19 cells Normal Homo sapiens CVCL_0145
HT-29 cells Colon adenocarcinoma Homo sapiens CVCL_0320
SH-SY5Y cells Neuroblastoma Homo sapiens CVCL_0019
Jurkat cells T acute lymphoblastic leukemia Homo sapiens CVCL_0065
Response regulation Sodium iodate (SI) is a widely used oxidant for generating retinal degeneration models by inducing the death of retinal pigment epithelium (RPE) cells. SI depletes GSH, increases ROS, releases labile iron, and boosts lipid damage, which in turn results in ferroptosis in ARPE-19 cells.
References
Ref 1 Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells. Cell Death Dis. 2021 Mar 3;12(3):230. doi: 10.1038/s41419-021-03520-2.