Ferroptosis-centered Disease Response Information

General Information of the Disease (ID: DIS00088)
Name
Age-related macular degeneration
ICD
ICD-11: 9B75
Full List of Target(s) of This Ferroptosis-centered Disease
Heme oxygenase 1 (HMOX1)
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Target for Ferroptosis Driver/Suppressor
Responsed Disease Age-related macular degeneration [ICD-11: 9B75]
Responsed Drug Sodium iodate Investigative
 Drug Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model ARPE-19 cells Normal Homo sapiens CVCL_0145
In Vivo Model
In this study, sixteen-week-old male C57BL/6 mice were used and housed in a standard laboratory environment. Forin vivostudies, left eyes were pretreated with a single intravitreal injection of DMSO (1 uL) or 1X PBS (1 uL), and right eyes were pretreated with Fer-1 (30 uM, a single intravitreal injection, 1 uL), DFO (100 uM, a single intravitreal injection, 1 uL), or ZnPP (50 mg/kg, intraperitoneal injection once a week). 15 min later, injection of NaIO3(35 mg/kg, a single injectionviatail vein), or 1X PBS (a single injectionviatail vein, 75 uL) has been performed. After 2 weeks, mice were used for subsequent experiments.

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Response regulation Sodium iodate-induced oxidative stress model has been identified to be heme oxygenase-1 (HO-1)-regulated ferroptosis, which is controlled by the Nrf2-SLC7A11-HO-1 hierarchy. These findings highlight that targeting HO-1-mediated RPE ferroptosis could serve as an effectively retinal-protective strategy for retinal degenerative diseases prevention, including age-related macular degeneration (AMD).
References
Ref 1 HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration. Redox Biol. 2021 Jul;43:101971. doi: 10.1016/j.redox.2021.101971. Epub 2021 Apr 17.