Ferroptosis-centered Drug Response Information
General Information of the Drug (ID: ferrodrug0007)
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Arsenic
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| Synonyms |
7440-38-2; Arsenic; As; Agent SA; Arsenowodor; Arsen; Arsenic hydride (AsH3); ARSENIC METAL; V1I29R0RJQ; Arsenicals; CHEBI:27563; Arsenic-75; Gray arsenic; Colloidal arsenic; Arsenic, inorganic; Arsenicals; Arsenic, inorganic; Arsen; CCRIS 55; Arsenic 75; HSDB 509; HSDB 510; Arsenic - As @ 1000 microg/g in Hydrocarbon Oil; EINECS 231-148-6; EINECS 232-066-3; UN2188; Arsenic Standard: As @ 1000 microg/mL in 5% HNO3; UNII-V1I29R0RJQ; Arsenic Standard: As @ 10000 microg/mL in 5% HNO3; arsenico; arsenicum; Arsenic AA Standard: As @ 1000 microg/mL in 5% HNO3; Arsinidene; arsenic atom; Arsenic sponge; UNII-N712M78A8G; Arsenic, lump; Inorganic arsenic; ARSINO; 04 - Elements; 19 - Lipstick; 21 - Powder sample; 2B - Trace elements; ARSENIC, SOLID; ARSENIC, METALLIC; 20 - Lip gloss sample; ARSINE [MI]; ARSENIC, (SOLID); ARSENICUM METALLICUM; 33As; Cannabis Target Elements-A; EC 232-066-3; S36 - Organic Fertilizer; ARSENIC METAL: ARSENIA; Arsenic - As @1000ug/mL; 62 - Saline Water - Metals; DTXCID703886; 13 - Sewage Sludge Inorganics; CHEMBL1231052; DTXSID3023760; DTXSID4023886; CHEBI:35826; 104 - Saline Water - Metals; RQNWIZPPADIBDY-UHFFFAOYSA-N; DTXSID201080837; DTXSID501080836; N712M78A8G; 02 - Sample 2 Cane/Beet Sugar; Arsenic, >=99.999%, pieces; 14 - Agricultural Soil Inorganics; Arsine [UN2188] [Poison gas]; AKOS015902733; Arsenic, 99.999% trace metals basis; 2 - Minerals and elements in animal feed; FT-0696579; C06269; 14 - Elemental contamination in herbal supplement; 17 - Elemental contamination in Pollen supplement; Arsenic, powder, >=99.997% trace metals basis; 8 - Minerals and trace elements in premix materials; Arsenic Standard: As @ 10 microg/mL in 2% HNO3; ARSENIC AND INORGANIC ARSENIC COMPOUNDS (IARC); Q21060492; Arsenic Standard: As @ 1000 microg/g in Hydrocarbon Oil; Arizona Heavy Metal Mixture 4-12 microg/mL in 2%HNO3, 1%HCl; AQ-14-QC sample 14 - Agricultural Soil Inorganics and Specific Elements; California Heavy Metal Mixture 5-30 microg/mL in 2% HNO3, 1% HCl; Cannabis Target Elements Mixture A 1-5 microg/mL in 2% HNO3, 1% HCl; Colorado Heavy Metal Mixture 40-100 microg/mL in 2% HNO3, 1% HCl; New Hampshire Heavy Metal Mixture 3-9 microg/mL in 2% HNO3, 1% HCl; Pennsylvania Heavy Metal Mixture 3-15 microg/mL in 2% HNO3, 1% HCl; Vermont Heavy Metal Mixture 20-100 microg/mL in 2% HNO3, 1% HCl; Washington Heavy Metal Mixture 40-200 microg/mL in 2% HNO3, 1% HCl; Arsenic polycrystalline lump, 2-8mm (0.08-0.3in), 99.9999% (metals basis); Arsenic polycrystalline lump, 2-8mm (0.08-0.3in), 99.99999% (metals basis); Connecticut, Michigan, Nevada Heavy Metal Mixture 9-29 microg/mL in 2% HNO3, 1% HCl
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| Structure |
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3D MOL
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| Formula |
As
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| IUPAC Name |
arsenic
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| Canonical SMILES |
[As]
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| InChI |
InChI=1S/As
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| InChIKey |
RQNWIZPPADIBDY-UHFFFAOYSA-N
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| PubChem CID | |||||
Full List of Ferroptosis Target Related to This Drug
Long-chain-fatty-acid--CoA ligase 4 (ACSL4)
| In total 1 item(s) under this Target | |||||
| Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | ||||
| Target for Ferroptosis | Driver | ||||
| Responsed Disease | Nonalcoholic fatty liver disease | ICD-11: DB92 | |||
| Responsed Regulator | Mitofusin-2 (MFN2) | Driver | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Cell Process | Cell ferroptosis | ||||
| In Vitro Model | L-02 cells | Endocervical adenocarcinoma | Homo sapiens | CVCL_6926 | |
| In Vivo Model |
Adult male Sprague-Dawley rats (300 g-350 g, specific pathogen free) were obtained from Institute of Genome Engineered Animal Models for Human Disease of Dalian Medical University (Dalian, China). To explore the influence of NaAsO2 (CAS No.7784-46-5, Sigma-Aldrich, USA) on the liver, the rats were subjected to NaAsO2 at the dosage of 0, 2.5, and 5 mg/kg by gavage for 9 months. The control group was gavaged with distilled water as vehicle.
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| Response regulation | Arsenic induces rat liver nonalcoholic steatohepatitis (NASH) and Ferroptosis via interacting between Mitofusin-2 with IRE1. NaAsO2 increases IRE1 and Mfn2 expression, subsequently led to upregulated ACSL4 expression and 5-HETE via the directly combination Mfn2 with IRE1, ultimately induced ferroptotic cell death. | ||||
Unspecific Target
| In total 1 item(s) under this Target | |||||
| Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [2] | ||||
| Responsed Disease | Pancreatic dysfunction | ICD-11: DC35 | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Ferroptosis | hsa04216 | ||||
| Autophagy | hsa04140 | ||||
| Cell Process | Cell ferroptosis | ||||
| Autophagy | |||||
| In Vitro Model | MIN6 cells | Insulinoma | Mus musculus | CVCL_0431 | |
| In Vivo Model |
Groups of 18 specific pathogen free (SPF) Adult male Sprague-Dawley rats (300 g -350 g) obtained from Institute of Genome Engineered Animal Models for Human Disease of Dalian Medical University (China). The rats were divided randomly into 3 groups, control, low-dose of NaAsO2 (2.5 mg/kg) and high-dose of NaAsO2 (5 mg/kg), 6 animals in each group. NaAsO2 (CAS No. 7784-46-5) was gained from Sigma Aldrich. The rats were subjected to NaAsO2 at a dose of 0, 2.5 and 5 mg/kg by gavage for 5 months. Control group was given distilled water using the above method.
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| Response regulation | Sodium arsenite-induced ferroptotic cell death is relied on the MtROS-dependent autophagy by regulating the iron homeostasis. Ferroptosis is involved in pancreatic dysfunction triggered by arsenic, and arsenic-induced ferroptosis involves MtROS, autophagy, ferritin. | ||||
References