Ferroptosis-centered Disease Response Information

General Information of the Disease (ID: DIS00116)
Name
Pancreatic dysfunction
ICD
ICD-11: DC35
Full List of Target(s) of This Ferroptosis-centered Disease
Unspecific Target
In total 2 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Responsed Disease Pancreatic dysfunction [ICD-11: DC35]
Responsed Drug Arsenic Investigative
 Drug Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Autophagy hsa04140
Cell Process Cell ferroptosis
Autophagy
In Vitro Model MIN6 cells Insulinoma Mus musculus CVCL_0431
In Vivo Model
Groups of 18 specific pathogen free (SPF) Adult male Sprague-Dawley rats (300 g -350 g) obtained from Institute of Genome Engineered Animal Models for Human Disease of Dalian Medical University (China). The rats were divided randomly into 3 groups, control, low-dose of NaAsO2 (2.5 mg/kg) and high-dose of NaAsO2 (5 mg/kg), 6 animals in each group. NaAsO2 (CAS No. 7784-46-5) was gained from Sigma Aldrich. The rats were subjected to NaAsO2 at a dose of 0, 2.5 and 5 mg/kg by gavage for 5 months. Control group was given distilled water using the above method.

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Response regulation Sodium arsenite-induced ferroptotic cell death is relied on the MtROS-dependent autophagy by regulating the iron homeostasis. Ferroptosis is involved in pancreatic dysfunction triggered by arsenic, and arsenic-induced ferroptosis involves MtROS, autophagy, ferritin.
Experiment 2 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Responsed Disease Pancreatic dysfunction [ICD-11: DC35]
Responsed Drug Sodium arsenite Investigative
 Drug Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Autophagy hsa04140
Cell Process Cell ferroptosis
Autophagy
In Vitro Model MIN6 cells Insulinoma Mus musculus CVCL_0431
In Vivo Model
Groups of 18 specific pathogen free (SPF) Adult male Sprague-Dawley rats (300 g -350 g) obtained from Institute of Genome Engineered Animal Models for Human Disease of Dalian Medical University (China). The rats were divided randomly into 3 groups, control, low-dose of NaAsO2 (2.5 mg/kg) and high-dose of NaAsO2 (5 mg/kg), 6 animals in each group. NaAsO2 (CAS No. 7784-46-5) was gained from Sigma Aldrich. The rats were subjected to NaAsO2 at a dose of 0, 2.5 and 5 mg/kg by gavage for 5 months. Control group was given distilled water using the above method.

    Click to Show/Hide
Response regulation Sodium arsenite-induced ferroptotic cell death is relied on the MtROS-dependent autophagy by regulating the iron homeostasis. Ferroptosis is involved in pancreatic dysfunction triggered by arsenic, and arsenic-induced ferroptosis involves MtROS, autophagy, ferritin.
References
Ref 1 Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway. J Hazard Mater. 2020 Feb 15;384:121390. doi: 10.1016/j.jhazmat.2019.121390. Epub 2019 Oct 5.