Ferroptosis-centered Disease Response Information

General Information of the Disease (ID: DIS00034)
Name
Pleural mesothelioma
ICD
ICD-11: 2C26
Full List of Target(s) of This Ferroptosis-centered Disease
Solute carrier family 40 member 1 (SLC40A1)
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Target for Ferroptosis Marker/Suppressor
Responsed Disease Pleural mesothelioma [ICD-11: 2C26]
Responsed Regulator Carbonic anhydrase 9 (CA9) Suppressor
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Apoptosis hsa04210
Cell Process Cell ferroptosis
Cell apoptosis
Cell proliferation
Cell migration
In Vitro Model ACC-MESO1 cells Pleural mesothelioma Homo sapiens CVCL_5113
NCI-H2373 cells Pleural mesothelioma Homo sapiens CVCL_A533
NCI-H2052 cells Pleural mesothelioma Homo sapiens CVCL_1518
MET-5A cells Normal Homo sapiens CVCL_3749
Response regulation CA9 suppression by inhibitors (S4 and U104) decreased viability and migration of MM cells, accompanied by overexpression of TFRC, IREB1/2 and FPN1(SLC40A1) and by downregulation of FTH/FTL in Pleural mesothelioma.
Unspecific Target
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [2]
Responsed Disease Malignant mesothelioma [ICD-11: 2C26]
Responsed Drug Ringer's lactate Investigative
 Drug Info 
Pathway Response Ferroptosis hsa04216
Autophagy hsa04140
NF-kappa B signaling pathway hsa04064
Cell Process Cell ferroptosis
Cell autophagy
In Vitro Model Y-MESO-8A cells Pleural mesothelioma Homo sapiens CVCL_5188
NCI-H290 cells Pleural mesothelioma Homo sapiens CVCL_A555
LP-9 cells Normal Homo sapiens CVCL_E109
HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
Response regulation Ringer's lactate (PAL) induces selective ferroptosis of malignant mesothelioma (MM) cells. PAL-induced ferroptosis accompanied autophagic process in the early phase, as demonstrated by an increase in essential amino acids, LC3B-II, p62 and LAMP1, transforming into the later phase with boosted lipid peroxidation.
References
Ref 1 Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia. Redox Biol. 2019 Sep;26:101297. doi: 10.1016/j.redox.2019.101297. Epub 2019 Aug 10.
Ref 2 Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate. Redox Biol. 2021 Jul;43:101989. doi: 10.1016/j.redox.2021.101989. Epub 2021 Apr 23.