Ferroptosis-centered Drug Response Information
General Information of the Drug (ID: ferrodrug0367)
| Name |
Ringer's lactate
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| Synonyms |
Ringer's lactate; 8022-63-7; Ringer-lactate; Ringer's injection, lactated; Propanoic acid, 2-hydroxy-, monosodium salt, mixt. with calcium chloride (CaCl2), potassium chloride (KCl) and sodium chloride (NaCl)
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| Structure |
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3D MOL
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| Formula |
C3H6CaCl4KNa2O3
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| Canonical SMILES |
CC(C(=O)O)O.[Na].[Na+].[Cl-].[Cl-].[Cl-].[Cl-].[K+].[Ca+2]
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| InChI |
InChI=1S/C3H6O3.Ca.4ClH.K.2Na/c1-2(4)3(5)6;;;;;;;;/h2,4H,1H3,(H,5,6);;4*1H;;;/q;+2;;;;;+1;;+1/p-4
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| InChIKey |
ZEWYCNBZMPELPF-UHFFFAOYSA-J
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| PubChem CID | |||||
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
| In total 1 item(s) under this Target | ||||
| Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | |||
| Responsed Disease | Pleural mesothelioma | ICD-11: 2C26 | ||
| Pathway Response | Ferroptosis | hsa04216 | ||
| Autophagy | hsa04140 | |||
| NF-kappa B signaling pathway | hsa04064 | |||
| Cell Process | Cell ferroptosis | |||
| Cell autophagy | ||||
| In Vitro Model | Y-MESO-8A cells | Pleural mesothelioma | Homo sapiens | CVCL_5188 |
| NCI-H290 cells | Pleural mesothelioma | Homo sapiens | CVCL_A555 | |
| LP-9 cells | Normal | Homo sapiens | CVCL_E109 | |
| HT-1080 cells | Fibrosarcoma | Homo sapiens | CVCL_0317 | |
| Response regulation | Ringer's lactate (PAL) induces selective ferroptosis of malignant mesothelioma (MM) cells. PAL-induced ferroptosis accompanied autophagic process in the early phase, as demonstrated by an increase in essential amino acids, LC3B-II, p62 and LAMP1, transforming into the later phase with boosted lipid peroxidation. | |||