Ferroptosis Regulator Information
General Information of the Ferroptosis Regulator (ID: REG40047)
Regulator Name | Circ_STC2 (circRNA) | ||||
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Synonyms |
Circ_STC2
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Gene Name | Circ_STC2 | ||||
Regulator Type | circRNA |
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
Circ_STC2
can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Transferrin receptor protein 2 (TFR2) [Driver]
In total 1 item(s) under this target | ||||
Experiment 1 Reporting the Ferroptosis Target of This Regulator | [1] | |||
Target for Ferroptosis | Driver | |||
Responsed Disease | Intervertebral disc degeneration | ICD-11: FA80 | ||
Pathway Response | Fatty acid metabolism | hsa01212 | ||
Ferroptosis | hsa04216 | |||
Cell Process | Cell ferroptosis | |||
Cell proliferation | ||||
In Vitro Model |
hNPCs (Human nucleus pulposus cells) | |||
Response regulation | Circ-STC2 and TFR2 expressions were up-regulated in intervertebral disc degeneration (IDD) tissues, and miR-486-3p expression was down-regulated. Circ-STC2 inhibits the cell viability, induced the ferroptosis of the TBHP treated NPCs via targeting miR-486-3p/TFR2 axis. | |||
Intervertebral disc degeneration [ICD-11: FA80]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the Ferroptosis-centered Disease Response | [1] | |||
Target Regulator | Circ_STC2 (circRNA) | circRNA | ||
Pathway Response | Fatty acid metabolism | hsa01212 | ||
Ferroptosis | hsa04216 | |||
Cell Process | Cell ferroptosis | |||
Cell proliferation | ||||
In Vitro Model |
hNPCs (Human nucleus pulposus cells) | |||
Response regulation | Circ-STC2 and TFR2 expressions were up-regulated in intervertebral disc degeneration (IDD) tissues, and miR-486-3p expression was down-regulated. Circ-STC2 inhibits the cell viability, induced the ferroptosis of the TBHP treated NPCs via targeting miR-486-3p/TFR2 axis. | |||