Ferroptosis Regulator Information
General Information of the Ferroptosis Regulator (ID: REG40032)
| Regulator Name | Cir93 (circRNA) | ||||
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| Synonyms |
Cir93
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| Gene Name | Cir93 | ||||
| Regulator Type | circRNA | ||||
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
Cir93
can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Lysophospholipid acyltransferase 5 (LPCAT3) [Driver]
| In total 1 item(s) under this target | |||||
| Experiment 1 Reporting the Ferroptosis Target of This Regulator | [1] | ||||
| Target for Ferroptosis | Driver | ||||
| Responsed Disease | Lung cancer | ICD-11: 2C25 | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Cell Process | Cell ferroptosis | ||||
| Cell proliferation | |||||
In Vitro Model |
H1650-ER1 cells | Minimally invasive lung adenocarcinoma | Homo sapiens | CVCL_4V01 | |
| PC-9 cells | Lung adenocarcinoma | Homo sapiens | CVCL_B260 | ||
| NCI-H1975 cells | Lung adenocarcinoma | Homo sapiens | CVCL_1511 | ||
| NCI-H358 cells | Minimally invasive lung adenocarcinoma | Homo sapiens | CVCL_1559 | ||
| A-549 cells | Lung adenocarcinoma | Homo sapiens | CVCL_0023 | ||
| NCI-H1299 cells | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | ||
| MRC-5 cells | Normal | Homo sapiens | CVCL_0440 | ||
| In Vivo Model |
All athymic nude mice (6-week-old) were purchased from Jiesijie (Shanghai, China). To generate routine cell-derived xenograft (CDX) mouse models, established LUAD cells (initial 5 x 106) were subcutaneously injected into the bilateral dorsal flank of athymic nude mice. To generate H1975/A549 cell-implanted intrapulmonary LUAD mice, athymic nude mice were intrapulmonarily injected with cells (5 x 106) under anesthesia and then intranasally administered adeno-associated virus 5 (AAV5) particles (2 x 1012 viral particles/mL, Genomeditech, Shanghai, China) 3 weeks later. To generate patient-derived xenograft (PDX) mouse models, fresh LUAD tissues with a size of 2-3 mm3 were subcutaneously implanted into athymic nude mice. After successful passage, the PDX mice were used for further studies.
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| Response regulation | Intracellular cir93-FABP3 interactions are critical to upregulate FABP3 to reduce global AA via reactions with taurine. The product of AA and taurine (i.e., NAT) prevents AA incorporation into the plasma membrane, thus further reducing the opportunity for PUFA peroxidation in the membrane. NAT reduces ACSL4, LPCAT3 and PLTP. Exosome and cir93 are critical to desensitize lung adenocarcinoma to ferroptosis. | ||||
Long-chain-fatty-acid--CoA ligase 4 (ACSL4) [Driver]
| In total 1 item(s) under this target | |||||
| Experiment 1 Reporting the Ferroptosis Target of This Regulator | [1] | ||||
| Target for Ferroptosis | Driver | ||||
| Responsed Disease | Lung cancer | ICD-11: 2C25 | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Cell Process | Cell ferroptosis | ||||
| Cell proliferation | |||||
In Vitro Model |
H1650-ER1 cells | Minimally invasive lung adenocarcinoma | Homo sapiens | CVCL_4V01 | |
| PC-9 cells | Lung adenocarcinoma | Homo sapiens | CVCL_B260 | ||
| NCI-H1975 cells | Lung adenocarcinoma | Homo sapiens | CVCL_1511 | ||
| NCI-H358 cells | Minimally invasive lung adenocarcinoma | Homo sapiens | CVCL_1559 | ||
| A-549 cells | Lung adenocarcinoma | Homo sapiens | CVCL_0023 | ||
| NCI-H1299 cells | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | ||
| MRC-5 cells | Normal | Homo sapiens | CVCL_0440 | ||
| In Vivo Model |
All athymic nude mice (6-week-old) were purchased from Jiesijie (Shanghai, China). To generate routine cell-derived xenograft (CDX) mouse models, established LUAD cells (initial 5 x 106) were subcutaneously injected into the bilateral dorsal flank of athymic nude mice. To generate H1975/A549 cell-implanted intrapulmonary LUAD mice, athymic nude mice were intrapulmonarily injected with cells (5 x 106) under anesthesia and then intranasally administered adeno-associated virus 5 (AAV5) particles (2 x 1012 viral particles/mL, Genomeditech, Shanghai, China) 3 weeks later. To generate patient-derived xenograft (PDX) mouse models, fresh LUAD tissues with a size of 2-3 mm3 were subcutaneously implanted into athymic nude mice. After successful passage, the PDX mice were used for further studies.
Click to Show/Hide
|
||||
| Response regulation | Intracellular cir93 FABP3 interactions are critical to upregulate FABP3 to reduce global AA via reactions with taurine. The product of AA and taurine (i.e., NAT) prevents AA incorporation into the plasma membrane, thus further reducing the opportunity for PUFA peroxidation in the membrane. NAT reduces ACSL4, LPCAT3 and PLTP. Exosome and cir93 are critical to desensitize lung adenocarcinoma to ferroptosis. | ||||
Lung cancer [ICD-11: 2C25]
| In total 2 item(s) under this disease | |||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response | [1] | ||||
| Target Regulator | Cir93 (circRNA) | circRNA | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Cell Process | Cell ferroptosis | ||||
| Cell proliferation | |||||
In Vitro Model |
H1650-ER1 cells | Minimally invasive lung adenocarcinoma | Homo sapiens | CVCL_4V01 | |
| PC-9 cells | Lung adenocarcinoma | Homo sapiens | CVCL_B260 | ||
| NCI-H1975 cells | Lung adenocarcinoma | Homo sapiens | CVCL_1511 | ||
| NCI-H358 cells | Minimally invasive lung adenocarcinoma | Homo sapiens | CVCL_1559 | ||
| A-549 cells | Lung adenocarcinoma | Homo sapiens | CVCL_0023 | ||
| NCI-H1299 cells | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | ||
| MRC-5 cells | Normal | Homo sapiens | CVCL_0440 | ||
| In Vivo Model |
All athymic nude mice (6-week-old) were purchased from Jiesijie (Shanghai, China). To generate routine cell-derived xenograft (CDX) mouse models, established LUAD cells (initial 5 x 106) were subcutaneously injected into the bilateral dorsal flank of athymic nude mice. To generate H1975/A549 cell-implanted intrapulmonary LUAD mice, athymic nude mice were intrapulmonarily injected with cells (5 x 106) under anesthesia and then intranasally administered adeno-associated virus 5 (AAV5) particles (2 x 1012 viral particles/mL, Genomeditech, Shanghai, China) 3 weeks later. To generate patient-derived xenograft (PDX) mouse models, fresh LUAD tissues with a size of 2-3 mm3 were subcutaneously implanted into athymic nude mice. After successful passage, the PDX mice were used for further studies.
Click to Show/Hide
|
||||
| Response regulation | Intracellular cir93-FABP3 interactions are critical to upregulate FABP3 to reduce global AA via reactions with taurine. The product of AA and taurine (i.e., NAT) prevents AA incorporation into the plasma membrane, thus further reducing the opportunity for PUFA peroxidation in the membrane. NAT reduces ACSL4, LPCAT3 and PLTP. Exosome and cir93 are critical to desensitize lung adenocarcinoma to ferroptosis. | ||||
| Experiment 2 Reporting the Ferroptosis-centered Disease Response | [1] | ||||
| Target Regulator | Cir93 (circRNA) | circRNA | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Cell Process | Cell ferroptosis | ||||
| Cell proliferation | |||||
In Vitro Model |
H1650-ER1 cells | Minimally invasive lung adenocarcinoma | Homo sapiens | CVCL_4V01 | |
| PC-9 cells | Lung adenocarcinoma | Homo sapiens | CVCL_B260 | ||
| NCI-H1975 cells | Lung adenocarcinoma | Homo sapiens | CVCL_1511 | ||
| NCI-H358 cells | Minimally invasive lung adenocarcinoma | Homo sapiens | CVCL_1559 | ||
| A-549 cells | Lung adenocarcinoma | Homo sapiens | CVCL_0023 | ||
| NCI-H1299 cells | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | ||
| MRC-5 cells | Normal | Homo sapiens | CVCL_0440 | ||
| In Vivo Model |
All athymic nude mice (6-week-old) were purchased from Jiesijie (Shanghai, China). To generate routine cell-derived xenograft (CDX) mouse models, established LUAD cells (initial 5 x 106) were subcutaneously injected into the bilateral dorsal flank of athymic nude mice. To generate H1975/A549 cell-implanted intrapulmonary LUAD mice, athymic nude mice were intrapulmonarily injected with cells (5 x 106) under anesthesia and then intranasally administered adeno-associated virus 5 (AAV5) particles (2 x 1012 viral particles/mL, Genomeditech, Shanghai, China) 3 weeks later. To generate patient-derived xenograft (PDX) mouse models, fresh LUAD tissues with a size of 2-3 mm3 were subcutaneously implanted into athymic nude mice. After successful passage, the PDX mice were used for further studies.
Click to Show/Hide
|
||||
| Response regulation | Intracellular cir93 FABP3 interactions are critical to upregulate FABP3 to reduce global AA via reactions with taurine. The product of AA and taurine (i.e., NAT) prevents AA incorporation into the plasma membrane, thus further reducing the opportunity for PUFA peroxidation in the membrane. NAT reduces ACSL4, LPCAT3 and PLTP. Exosome and cir93 are critical to desensitize lung adenocarcinoma to ferroptosis. | ||||