Ferroptosis Regulator Information
General Information of the Ferroptosis Regulator (ID: REG40030)
| Regulator Name | CircEXOC5 (circRNA) | ||||
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| Synonyms |
CircEXOC5
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| Gene Name | CircEXOC5 | ||||
| Regulator Type | circRNA | ||||
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
CircEXOC5
can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Long-chain-fatty-acid--CoA ligase 4 (ACSL4) [Driver]
| In total 1 item(s) under this target | |||||
| Experiment 1 Reporting the Ferroptosis Target of This Regulator | [1] | ||||
| Target for Ferroptosis | Driver | ||||
| Responsed Disease | Lung injury | ICD-11: NB32 | |||
| Pathway Response | Ferroptosis | hsa04216 | |||
| Cell Process | Cell ferroptosis | ||||
In Vitro Model |
mLVECs (Mouse lung microvascular endothelial cells) | ||||
| In Vivo Model |
The sepsis mouse model was established by cecal ligation and puncture (CLP) of male C57BL/6 mouse (6-8 weeks, Guangzhou Animal Medical Center). Firstly, the mice were anesthetized by intraperitoneal injection of 4% chloral hydrate (0.1 ml/10g). The cecum was found by cutting a 1 cm longitudinally in the abdomen of the mice, and ligating the cecum from the end of the cecum to half the length of the ileocecal valve with 5-0 silk suture. Then a 21 G needle was used to puncture the ligature and the midpoint of the cecum once, and finally the wound was sutured. In the sham operation group, only laparotomy was performed, without ligation and perforation of the cecum. All animal-related experiments in this study were approved by hospital ethics committee according to following the Nation Institutes of Health Guide for the Laboratory Animals Care and Use (approval No. Med-Eth-Re [2022] 168).
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| Response regulation | CircEXOC5 can enhance the stability of the target gene ACSL4 by binding to the RNA binding protein PTBP1 and up-regulate its expression, thereby promoting ferroptosis and exacerbating sepsis-induced acute lung injury. | ||||
Lung injury [ICD-11: NB32]
| In total 1 item(s) under this disease | |||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response | [1] | ||||
| Target Regulator | CircEXOC5 (circRNA) | circRNA | |||
| Pathway Response | Ferroptosis | hsa04216 | |||
| Cell Process | Cell ferroptosis | ||||
In Vitro Model |
mLVECs (Mouse lung microvascular endothelial cells) | ||||
| In Vivo Model |
The sepsis mouse model was established by cecal ligation and puncture (CLP) of male C57BL/6 mouse (6-8 weeks, Guangzhou Animal Medical Center). Firstly, the mice were anesthetized by intraperitoneal injection of 4% chloral hydrate (0.1 ml/10g). The cecum was found by cutting a 1 cm longitudinally in the abdomen of the mice, and ligating the cecum from the end of the cecum to half the length of the ileocecal valve with 5-0 silk suture. Then a 21 G needle was used to puncture the ligature and the midpoint of the cecum once, and finally the wound was sutured. In the sham operation group, only laparotomy was performed, without ligation and perforation of the cecum. All animal-related experiments in this study were approved by hospital ethics committee according to following the Nation Institutes of Health Guide for the Laboratory Animals Care and Use (approval No. Med-Eth-Re [2022] 168).
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| Response regulation | CircEXOC5 can enhance the stability of the target gene ACSL4 by binding to the RNA binding protein PTBP1 and up-regulate its expression, thereby promoting ferroptosis and exacerbating sepsis-induced acute lung injury. | ||||