Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG40027)
Regulator Name CircSCN8A (circRNA)
Synonyms
CircSCN8A
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Gene Name CircSCN8A
Regulator Type circRNA
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
CircSCN8A can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
Browse Target
Browse Disease
Long-chain-fatty-acid--CoA ligase 4 (ACSL4) [Driver]
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Target for Ferroptosis Driver
Responsed Disease Lung cancer ICD-11: 2C25
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
In Vitro Model
 A-549 cells Lung adenocarcinoma Homo sapiens CVCL_0023
NCI-H1299 cells Lung large cell carcinoma Homo sapiens CVCL_0060
NCI-H520 cells Lung squamous cell carcinoma Homo sapiens CVCL_1566
SK-MES-1 cells Lung squamous cell carcinoma Homo sapiens CVCL_0630
BEAS-2B cells Normal Homo sapiens CVCL_0168
In Vivo Model
Male BALB/c nude mice (3-4 weeks, 16-20 g) were purchased from Vital River Laboratory (Beijing, China) and housed under standard conditions. After acclimatization for one week, mice were randomly divided into two groups (n = 6/group). A549 cells infected with lentivirus circSCN8A (Lv-circSNC8A) or control (Lv-vector) were selected in the presence of puromycin (1 ug/ml). A549 cells (7 x 106) with Lv-circSNC8A or Lv-vector were suspended in 100 uL PBS and respectively injected into each mouse at the right flank.

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Response regulation CircSCN8A represses cell proliferation and metastasis in NSCLC by regulating the miR-1290/ACSL4 axis to induce ferroptosis. Thus, circSCN8A may represent a promising therapeutic target against NSCLC.
Lung cancer [ICD-11: 2C25]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator CircSCN8A (circRNA) circRNA
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
In Vitro Model
 A-549 cells Lung adenocarcinoma Homo sapiens CVCL_0023
NCI-H1299 cells Lung large cell carcinoma Homo sapiens CVCL_0060
NCI-H520 cells Lung squamous cell carcinoma Homo sapiens CVCL_1566
SK-MES-1 cells Lung squamous cell carcinoma Homo sapiens CVCL_0630
BEAS-2B cells Normal Homo sapiens CVCL_0168
In Vivo Model
Male BALB/c nude mice (3-4 weeks, 16-20 g) were purchased from Vital River Laboratory (Beijing, China) and housed under standard conditions. After acclimatization for one week, mice were randomly divided into two groups (n = 6/group). A549 cells infected with lentivirus circSCN8A (Lv-circSNC8A) or control (Lv-vector) were selected in the presence of puromycin (1 ug/ml). A549 cells (7 x 106) with Lv-circSNC8A or Lv-vector were suspended in 100 uL PBS and respectively injected into each mouse at the right flank.

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Response regulation CircSCN8A represses cell proliferation and metastasis in NSCLC by regulating the miR-1290/ACSL4 axis to induce ferroptosis. Thus, circSCN8A may represent a promising therapeutic target against NSCLC.
References
Ref 1 CircSCN8A suppresses malignant progression and induces ferroptosis in non-small cell lung cancer by regulating miR-1290/ACSL4 axis. Cell Cycle. 2023 Apr;22(7):758-776. doi: 10.1080/15384101.2022.2154543. Epub 2022 Dec 8.