Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG40017)
Regulator Name Circ0097009 (circRNA)
Synonyms
Circ0097009
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Gene Name Circ0097009
Regulator Type circRNA
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
Circ0097009 can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
Browse Target
Browse Disease
Cystine/glutamate transporter (SLC7A11) [Driver; Suppressor]
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Target for Ferroptosis Suppressor
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell proliferation
Cell invasion
Cell metastasis
In Vitro Model
 L-02 cells Endocervical adenocarcinoma Homo sapiens CVCL_6926
Hep-G2 cells Hepatoblastoma Homo sapiens CVCL_0027
BEL-7402 cells Endocervical adenocarcinoma Homo sapiens CVCL_5492
MHCC97-H cells Adult hepatocellular carcinoma Homo sapiens CVCL_4972
In Vivo Model
Four-week-old female BALB/c nude mice were subcutaneously inoculated with 2 x 106 cells (5 mice per group). Intratumoral injection (40 uL of si-circ0097009 or negative control siRNA) was administered every 4 days. Mice were sacrificed, and tumor weights were measured after 4 weeks. To establish lung metastases, HepG2 cells were treated with 20 umol/L si-circ0097009. After 48 hours, cells (1 x 105) were intravenously injected into the tail veins of mice (6 mice per group).

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Response regulation Circ0097009 acts as a competing endogenous RNA to regulate the expression of SLC7A11, a key regulator of cancer cell ferroptosis, by sponging miR-1261 in hepatocellular cancer. Circ0097009 may be used as a diagnostic biomarker for Hepatocellular carcinoma and as a potential target for HCC therapy.
Hepatocellular carcinoma [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator Circ0097009 (circRNA) circRNA
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell proliferation
Cell invasion
Cell metastasis
In Vitro Model
 L-02 cells Endocervical adenocarcinoma Homo sapiens CVCL_6926
Hep-G2 cells Hepatoblastoma Homo sapiens CVCL_0027
BEL-7402 cells Endocervical adenocarcinoma Homo sapiens CVCL_5492
MHCC97-H cells Adult hepatocellular carcinoma Homo sapiens CVCL_4972
In Vivo Model
Four-week-old female BALB/c nude mice were subcutaneously inoculated with 2 x 106 cells (5 mice per group). Intratumoral injection (40 uL of si-circ0097009 or negative control siRNA) was administered every 4 days. Mice were sacrificed, and tumor weights were measured after 4 weeks. To establish lung metastases, HepG2 cells were treated with 20 umol/L si-circ0097009. After 48 hours, cells (1 x 105) were intravenously injected into the tail veins of mice (6 mice per group).

    Click to Show/Hide
Response regulation Circ0097009 acts as a competing endogenous RNA to regulate the expression of SLC7A11, a key regulator of cancer cell ferroptosis, by sponging miR-1261 in hepatocellular cancer. Circ0097009 may be used as a diagnostic biomarker for Hepatocellular carcinoma and as a potential target for HCC therapy.
References
Ref 1 Ferroptosis is involved in the progression of hepatocellular carcinoma through the circ0097009/miR-1261/SLC7A11 axis. Ann Transl Med. 2021 Apr;9(8):675. doi: 10.21037/atm-21-997.