Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG40004)
Regulator Name CircACAP2 (circRNA)
Synonyms
CircACAP2
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Gene Name CircACAP2
Regulator Type circRNA
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
CircACAP2 can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Phospholipid hydroperoxide glutathione peroxidase (GPX4) [Suppressor]
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Target for Ferroptosis Suppressor
Responsed Disease Cervical cancer ICD-11: 2C77
 Disease Info 
Pathway Response Ferroptosis hsa04216
Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
In Vitro Model
 SiHa cells Cervical squamous cell carcinoma Homo sapiens CVCL_0032
HeLa cells Endocervical adenocarcinoma Homo sapiens CVCL_0030
Response regulation miR-193a-5p was able to target GPX4 and circACAP2 promoted GPX4 expression by sponging miR-193a-5p in cervical cancer cells.Therefore, we concluded that circular RNA circACAP2 repressed ferroptosis of cervical cancer during malignant progression by miR-193a-5p/GPX4.
Cervical cancer [ICD-11: 2C77]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator CircACAP2 (circRNA) circRNA
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
In Vitro Model
 SiHa cells Cervical squamous cell carcinoma Homo sapiens CVCL_0032
HeLa cells Endocervical adenocarcinoma Homo sapiens CVCL_0030
Response regulation miR-193a-5p was able to target GPX4 and circACAP2 promoted GPX4 expression by sponging miR-193a-5p in cervical cancer cells.Therefore, we concluded that circular RNA circACAP2 repressed ferroptosis of cervical cancer during malignant progression by miR-193a-5p/GPX4.
References
Ref 1 Circular RNA circACAP2 Suppresses Ferroptosis of Cervical Cancer during Malignant Progression by miR-193a-5p/GPX4. J Oncol. 2022 Jul 8;2022:5228874. doi: 10.1155/2022/5228874. eCollection 2022.