Ferroptosis Regulator Information
General Information of the Ferroptosis Regulator (ID: REG40002)
Regulator Name | CircDTL (circRNA) | ||||
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Synonyms |
CircDTL
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Gene Name | CircDTL | ||||
Regulator Type | circRNA |
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
CircDTL
can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Phospholipid hydroperoxide glutathione peroxidase (GPX4) [Suppressor]
In total 1 item(s) under this target | |||||
Experiment 1 Reporting the Ferroptosis Target of This Regulator | [1] | ||||
Target for Ferroptosis | Suppressor | ||||
Responsed Disease | Lung cancer | ICD-11: 2C25 | |||
Pathway Response | Fatty acid metabolism | hsa01212 | |||
Ferroptosis | hsa04216 | ||||
Apoptosis | hsa04210 | ||||
Cell Process | Cell ferroptosis | ||||
Cell apoptosis | |||||
In Vitro Model |
BEAS-2B cells | Normal | Homo sapiens | CVCL_0168 | |
NCI-H23 cells | Lung adenocarcinoma | Homo sapiens | CVCL_1547 | ||
NCI-H522 cells | Non-small cell lung carcinoma | Homo sapiens | CVCL_1567 | ||
PC-9 cells | Lung adenocarcinoma | Homo sapiens | CVCL_B260 | ||
A-549 cells | Lung adenocarcinoma | Homo sapiens | CVCL_0023 | ||
In Vivo Model |
The Shanghai SLAC Animal Center (Shanghai, China) provided 4-6-week-old BALB/c male nude mice, which were kept according to the standards for the use and care of laboratory animals. A total of 1 x 107 NSCLC cells infected with shRNA were injected subcutaneously into the left flank of nude mice (3 per group). Every 3 days, the tumor volume was measured.
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Response regulation | It was identified that circDTL exerts its oncogenic effects via the circDTL/miR-1287-5p/GPX4 axis and GPX4 inhibits both ferroptosis and apoptosis. Finally, silencing of circDTL promoted the sensitivity of non-small cell lung cancer cells to chemotherapeutic agents and inhibited the growth of tumors in vivo. | ||||
Lung cancer [ICD-11: 2C25]
In total 1 item(s) under this disease | |||||
Experiment 1 Reporting the Ferroptosis-centered Disease Response | [1] | ||||
Target Regulator | CircDTL (circRNA) | circRNA | |||
Pathway Response | Fatty acid metabolism | hsa01212 | |||
Ferroptosis | hsa04216 | ||||
Apoptosis | hsa04210 | ||||
Cell Process | Cell ferroptosis | ||||
Cell apoptosis | |||||
In Vitro Model |
BEAS-2B cells | Normal | Homo sapiens | CVCL_0168 | |
NCI-H23 cells | Lung adenocarcinoma | Homo sapiens | CVCL_1547 | ||
NCI-H522 cells | Non-small cell lung carcinoma | Homo sapiens | CVCL_1567 | ||
PC-9 cells | Lung adenocarcinoma | Homo sapiens | CVCL_B260 | ||
A-549 cells | Lung adenocarcinoma | Homo sapiens | CVCL_0023 | ||
In Vivo Model |
The Shanghai SLAC Animal Center (Shanghai, China) provided 4-6-week-old BALB/c male nude mice, which were kept according to the standards for the use and care of laboratory animals. A total of 1 x 107 NSCLC cells infected with shRNA were injected subcutaneously into the left flank of nude mice (3 per group). Every 3 days, the tumor volume was measured.
Click to Show/Hide
|
||||
Response regulation | It was identified that circDTL exerts its oncogenic effects via the circDTL/miR-1287-5p/GPX4 axis and GPX4 inhibits both ferroptosis and apoptosis. Finally, silencing of circDTL promoted the sensitivity of non-small cell lung cancer cells to chemotherapeutic agents and inhibited the growth of tumors in vivo. | ||||