Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG30059)
Regulator Name LINC00976 (IncRNA)
Synonyms
CCDC26; MGC27434; RAM
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Gene Name LINC00976
Gene ID 137196
Regulator Type lncRNA
Ensembl ID ENSG00000229140
HGNC ID
HGNC:28416
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
LINC00976 can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
Browse Target
Browse Disease
Phospholipid hydroperoxide glutathione peroxidase (GPX4) [Suppressor]
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Target for Ferroptosis Suppressor
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12
 Disease Info 
Pathway Response Ferroptosis hsa04216
Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
In Vitro Model
 hIBECs (Human intrahepatic biliary epithelial cells)
HuCC-T1 cells Intrahepatic cholangiocarcinoma Homo sapiens CVCL_0324
HCCC-9810 cells Intrahepatic cholangiocarcinoma Homo sapiens CVCL_6908
QBC939 cells Cholangiocarcinoma Homo sapiens CVCL_6942
HuH-28 cells Cholangiocarcinoma Homo sapiens CVCL_2955
RBE cells Intrahepatic cholangiocarcinoma Homo sapiens CVCL_4896
In Vivo Model
For the proliferation assays, HuCCT1 cells with linc00976 knockdown, linc00976 overexpression, and negative control were subcutaneously injected into BALB/c nude mice. The mice were weighed every week and euthanized 5 weeks after injection. Finally, tumors were dissected and weighed. For the proliferation assays, HuCCT1 cells with linc00976 knockdown, linc00976 overexpression, and negative control were subcutaneously injected into BALB/c nude mice. The mice were weighed every week and euthanized 5 weeks after injection. Finally, tumors were dissected and weighed.

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Response regulation JUND promotes linc00976 transcription, and linc00976 plays a crucial role in accelerating Cholangiocarcinoma tumorigenesis and metastasis and inhibiting ferroptosis by modulating the miR-3202/GPX4 axis.
Hepatocellular carcinoma [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator LINC00976 (IncRNA) lncRNA
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
In Vitro Model
 hIBECs (Human intrahepatic biliary epithelial cells)
HuCC-T1 cells Intrahepatic cholangiocarcinoma Homo sapiens CVCL_0324
HCCC-9810 cells Intrahepatic cholangiocarcinoma Homo sapiens CVCL_6908
QBC939 cells Cholangiocarcinoma Homo sapiens CVCL_6942
HuH-28 cells Cholangiocarcinoma Homo sapiens CVCL_2955
RBE cells Intrahepatic cholangiocarcinoma Homo sapiens CVCL_4896
In Vivo Model
For the proliferation assays, HuCCT1 cells with linc00976 knockdown, linc00976 overexpression, and negative control were subcutaneously injected into BALB/c nude mice. The mice were weighed every week and euthanized 5 weeks after injection. Finally, tumors were dissected and weighed. For the proliferation assays, HuCCT1 cells with linc00976 knockdown, linc00976 overexpression, and negative control were subcutaneously injected into BALB/c nude mice. The mice were weighed every week and euthanized 5 weeks after injection. Finally, tumors were dissected and weighed.

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Response regulation JUND promotes linc00976 transcription, and linc00976 plays a crucial role in accelerating Cholangiocarcinoma tumorigenesis and metastasis and inhibiting ferroptosis by modulating the miR-3202/GPX4 axis.
References
Ref 1 JUND/linc00976 promotes cholangiocarcinoma progression and metastasis, inhibits ferroptosis by regulating the miR-3202/GPX4 axis. Cell Death Dis. 2022 Nov 18;13(11):967. doi: 10.1038/s41419-022-05412-5.