Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG30048)
Regulator Name LINC00597 (IncRNA)
Synonyms
LINC00597
    Click to Show/Hide
Gene Name LINC00597
Gene ID 81698
Regulator Type lncRNA
Ensembl ID .
HGNC ID
HGNC:1193
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
LINC00597 can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
Browse Target
Browse Disease
Transferrin receptor protein 1 (TFRC) [Driver; Suppressor; Marker]
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Target for Ferroptosis Marker/Suppressor/Driver
Responsed Disease Lung cancer ICD-11: 2C25
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 A-549 cells Lung adenocarcinoma Homo sapiens CVCL_0023
SK-MES-1 cells Lung squamous cell carcinoma Homo sapiens CVCL_0630
HEK-293T cells Normal Homo sapiens CVCL_0063
Response regulation This study indicated that cinobufotalin induced ferroptosis to suppress lung cancer cell growth by lncRNA LINC00597/hsa-miR-367-3p/TFRC pathway via resibufogenin might provide novel therapeutic targets for lung cancer therapy.
Lung cancer [ICD-11: 2C25]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator LINC00597 (IncRNA) lncRNA
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 A-549 cells Lung adenocarcinoma Homo sapiens CVCL_0023
SK-MES-1 cells Lung squamous cell carcinoma Homo sapiens CVCL_0630
HEK-293T cells Normal Homo sapiens CVCL_0063
Response regulation This study indicated that cinobufotalin induced ferroptosis to suppress lung cancer cell growth by lncRNA LINC00597/hsa-miR-367-3p/TFRC pathway via resibufogenin might provide novel therapeutic targets for lung cancer therapy.
References
Ref 1 Cinobufotalin Induces Ferroptosis to Suppress Lung Cancer Cell Growth by lncRNA LINC00597/hsa-miR-367-3p/TFRC Pathway via Resibufogenin. Anticancer Agents Med Chem. 2023;23(6):717-725. doi: 10.2174/1871520622666221010092922.