Ferroptosis Regulator Information
General Information of the Ferroptosis Regulator (ID: REG20057)
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
rno-miR-672-3p
can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Ferroptosis suppressor protein 1 (AIFM2) [Suppressor]
| In total 1 item(s) under this target | |||||
| Experiment 1 Reporting the Ferroptosis Target of This Regulator | [1] | ||||
| Target for Ferroptosis | Suppressor | ||||
| Responsed Disease | Spinal cord injury | ICD-11: ND51 | |||
| Pathway Response | Glutathione metabolism | hsa00480 | |||
| Ferroptosis | hsa04216 | ||||
| Cell Process | Cell ferroptosis | ||||
In Vitro Model |
AGE1.HN cells | Normal | Homo sapiens | CVCL_DF60 | |
| PC12 cells | Adrenal gland pheochromocytoma | Rattus norvegicus | CVCL_0481 | ||
| In Vivo Model |
Adult male Sprague-Dawley rats weighing 200-220 g were purchased from the Animal Center of the Medical Department of Xi'an Jiaotong University. The rats were anesthetized by intraperitoneal injection of 1% pentobarbital sodium (50 mg/kg), and the spines of the rats were fixed. The skin of T9-12 level was incised, and laminectomy was performed at the T10 level to expose the spinal cord. The rats were then placed in the appropriate position of the impactor so that 10 g of rod fell freely at a height of 3 cm and hit the center of the T10 level of the spinal cord. The signs of successful establishment of the model were the appearance of hind limb extension and tail-flick reflex in rats. Laminectomy was performed only in the sham-operated group. The rats in the SCI group received an artificial bladder massage twice a day to assist in urination until they were able to urinate.
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| Response regulation | miR-672-3p exerts a neural restoration effectin vivo and in vitro by inhibiting ferroptosis via the FSP1 pathway. In addition, miR-672-3p improved locomotor function in spinal cord injury rats, suggesting its potential as a target for the development of therapeutics for SCI. | ||||
Spinal cord injury [ICD-11: ND51]
| In total 1 item(s) under this disease | |||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response | [1] | ||||
| Target Regulator | rno-miR-672-3p (miRNA) | miRNA | |||
| Pathway Response | Glutathione metabolism | hsa00480 | |||
| Ferroptosis | hsa04216 | ||||
| Cell Process | Cell ferroptosis | ||||
In Vitro Model |
AGE1.HN cells | Normal | Homo sapiens | CVCL_DF60 | |
| PC12 cells | Adrenal gland pheochromocytoma | Rattus norvegicus | CVCL_0481 | ||
| In Vivo Model |
Adult male Sprague-Dawley rats weighing 200-220 g were purchased from the Animal Center of the Medical Department of Xi'an Jiaotong University. The rats were anesthetized by intraperitoneal injection of 1% pentobarbital sodium (50 mg/kg), and the spines of the rats were fixed. The skin of T9-12 level was incised, and laminectomy was performed at the T10 level to expose the spinal cord. The rats were then placed in the appropriate position of the impactor so that 10 g of rod fell freely at a height of 3 cm and hit the center of the T10 level of the spinal cord. The signs of successful establishment of the model were the appearance of hind limb extension and tail-flick reflex in rats. Laminectomy was performed only in the sham-operated group. The rats in the SCI group received an artificial bladder massage twice a day to assist in urination until they were able to urinate.
Click to Show/Hide
|
||||
| Response regulation | miR-672-3p exerts a neural restoration effectin vivo and in vitro by inhibiting ferroptosis via the FSP1 pathway. In addition, miR-672-3p improved locomotor function in spinal cord injury rats, suggesting its potential as a target for the development of therapeutics for SCI. | ||||