Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG10394)
Regulator Name Metallothionein-1A (MT1A)
Synonyms
MT1S; Metallothionein-IA
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Gene Name MT1A
Gene ID 4489
Regulator Type Protein coding
Uniprot ID P04731
Sequence
MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCC
A

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Family Metallothionein superfamily
Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

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HGNC ID
HGNC:7393
KEGG ID hsa:4489
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
MT1A can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Unspecific Target [Unspecific Target]
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Responsed Disease Acute myeloid leukaemia ICD-11: 2A60
 Disease Info 
Responsed Drug Dihydroartemisinin Investigative
 Drug Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 MOLM-14 cells Leukemia Homo sapiens CVCL_7916
OCI-AML-2 cells Acute myeloid leukemia Homo sapiens CVCL_1619
HL-60 cells Adult acute myeloid leukemia Homo sapiens CVCL_0002
SET-2 cells Acute megakaryoblastic leukemia Homo sapiens CVCL_2187
MV4-11 cells Childhood acute monocytic leukemia Homo sapiens CVCL_0064
K-562 cells Chronic myelogenous leukemia Homo sapiens CVCL_0004
THP-1 cells Childhood acute monocytic leukemia Homo sapiens CVCL_0006
UT-7/Epo cells Acute megakaryoblastic leukemia Homo sapiens CVCL_5202
SKM-1 cells Acute myeloid leukemia Homo sapiens CVCL_0098
NB4 cells Acute promyelocytic leukemia Homo sapiens CVCL_0005
Kasumi-1 cells Acute myeloid leukemia Homo sapiens CVCL_0589
Response regulation Dihydroartemisinin (DHA) activated zinc metabolism signaling, especially the upregulation of metallothionein (MT). DHA activates ferritinophagy and subsequent ferroptosis in AML and that MTs are involved in glutathione regenerating and antioxidant response in Acute Myeloid Leukemia.
Acute myeloid leukaemia [ICD-11: 2A60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator Metallothionein-1A (MT1A) Protein coding
 Regulator Info 
Responsed Drug Dihydroartemisinin Investigative
 Drug Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 MOLM-14 cells Leukemia Homo sapiens CVCL_7916
OCI-AML-2 cells Acute myeloid leukemia Homo sapiens CVCL_1619
HL-60 cells Adult acute myeloid leukemia Homo sapiens CVCL_0002
SET-2 cells Acute megakaryoblastic leukemia Homo sapiens CVCL_2187
MV4-11 cells Childhood acute monocytic leukemia Homo sapiens CVCL_0064
K-562 cells Chronic myelogenous leukemia Homo sapiens CVCL_0004
THP-1 cells Childhood acute monocytic leukemia Homo sapiens CVCL_0006
UT-7/Epo cells Acute megakaryoblastic leukemia Homo sapiens CVCL_5202
SKM-1 cells Acute myeloid leukemia Homo sapiens CVCL_0098
NB4 cells Acute promyelocytic leukemia Homo sapiens CVCL_0005
Kasumi-1 cells Acute myeloid leukemia Homo sapiens CVCL_0589
Response regulation Dihydroartemisinin (DHA) activated zinc metabolism signaling, especially the upregulation of metallothionein (MT). DHA activates ferritinophagy and subsequent ferroptosis in AML and that MTs are involved in glutathione regenerating and antioxidant response in Acute Myeloid Leukemia.
Dihydroartemisinin [Investigative]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the Ferroptosis-centered Drug Response [1]
Drug for Ferroptosis Inducer
Response Target Unspecific Target
Responsed Disease Acute myeloid leukaemia ICD-11: 2A60
 Disease Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 MOLM-14 cells Leukemia Homo sapiens CVCL_7916
OCI-AML-2 cells Acute myeloid leukemia Homo sapiens CVCL_1619
HL-60 cells Adult acute myeloid leukemia Homo sapiens CVCL_0002
SET-2 cells Acute megakaryoblastic leukemia Homo sapiens CVCL_2187
MV4-11 cells Childhood acute monocytic leukemia Homo sapiens CVCL_0064
K-562 cells Chronic myelogenous leukemia Homo sapiens CVCL_0004
THP-1 cells Childhood acute monocytic leukemia Homo sapiens CVCL_0006
UT-7/Epo cells Acute megakaryoblastic leukemia Homo sapiens CVCL_5202
SKM-1 cells Acute myeloid leukemia Homo sapiens CVCL_0098
NB4 cells Acute promyelocytic leukemia Homo sapiens CVCL_0005
Kasumi-1 cells Acute myeloid leukemia Homo sapiens CVCL_0589
Response regulation Dihydroartemisinin (DHA) activated zinc metabolism signaling, especially the upregulation of metallothionein (MT). DHA activates ferritinophagy and subsequent ferroptosis in AML and that MTs are involved in glutathione regenerating and antioxidant response in Acute Myeloid Leukemia.
References
Ref 1 Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein. Cell Death Discov. 2023 Mar 17;9(1):97. doi: 10.1038/s41420-023-01371-8.