Ferroptosis Regulator Information
General Information of the Ferroptosis Regulator (ID: REG10115)
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
ACO1
can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Unspecific Target [Unspecific Target]
In total 1 item(s) under this target | ||||
Experiment 1 Reporting the Ferroptosis Target of This Regulator | [1] | |||
Responsed Disease | Hereditary Leiomyomatosis | ICD-11: 2C90 | ||
Pathway Response | Fatty acid metabolism | hsa01212 | ||
Ferroptosis | hsa04216 | |||
Autophagy | hsa04140 | |||
Cell Process | Cell ferroptosis | |||
Cell autophagy | ||||
Cell proliferation | ||||
Cell metastasis | ||||
Cell invasion | ||||
In Vitro Model |
ACHN cells | Papillary renal cell carcinoma | Homo sapiens | CVCL_1067 |
Response regulation | ACO1 and IREB2 downregulation in kidney renal clear cell carcinoma were correlated with cancer aggressiveness, cellular iron homeostasis, cytotoxic immune cell infiltration, and patient survival outcomes. | |||
Hereditary Leiomyomatosis [ICD-11: 2C90]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the Ferroptosis-centered Disease Response | [1] | |||
Target Regulator | Cytoplasmic aconitate hydratase (ACO1) | Protein coding | ||
Pathway Response | Fatty acid metabolism | hsa01212 | ||
Ferroptosis | hsa04216 | |||
Autophagy | hsa04140 | |||
Cell Process | Cell ferroptosis | |||
Cell autophagy | ||||
Cell proliferation | ||||
Cell metastasis | ||||
Cell invasion | ||||
In Vitro Model |
ACHN cells | Papillary renal cell carcinoma | Homo sapiens | CVCL_1067 |
Response regulation | ACO1 and IREB2 downregulation in kidney renal clear cell carcinoma were correlated with cancer aggressiveness, cellular iron homeostasis, cytotoxic immune cell infiltration, and patient survival outcomes. | |||