Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG10057)
Regulator Name GTPase HRas (HRAS)
Synonyms
HRAS1; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21ras
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Gene Name HRAS
Gene ID 3265
Regulator Type Protein coding
Uniprot ID P01112
Sequence
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS

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Family Ras family
Function
Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

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HGNC ID
HGNC:5173
KEGG ID hsa:3265
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
HRAS can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Unspecific Target [Unspecific Target]
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Responsed Disease Rhabdomyosarcoma ICD-11: 2B55
 Disease Info 
Pathway Response Ferroptosis hsa04216
MAPK signaling pathway hsa04010
PI3K-Akt signaling pathway hsa04151
Apoptosis hsa04210
Cell Process Cell ferroptosis
Cell apoptosis
Cell proliferation
In Vitro Model
 RMS13 cells Rhabdomyosarcoma Mus musculus CVCL_S112
Response regulation Oncogenic RAS ( HRAS, NRAS, KRAS) selectively modulates cell death pathways triggered by cytotoxic stimuli in rhabdomyosarcoma RMS13 cells. In conclusion, our discovery of an increased resistance to oxidative stress imposed by oncogenic RAS mutants in RMS13 cells has important implications for the development of targeted therapies for rhabdomyosarcoma (RMS).
Rhabdomyosarcoma [ICD-11: 2B55]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator GTPase HRas (HRAS) Protein coding
 Regulator Info 
Pathway Response Ferroptosis hsa04216
MAPK signaling pathway hsa04010
PI3K-Akt signaling pathway hsa04151
Apoptosis hsa04210
Cell Process Cell ferroptosis
Cell apoptosis
Cell proliferation
In Vitro Model
 RMS13 cells Rhabdomyosarcoma Mus musculus CVCL_S112
Response regulation Oncogenic RAS ( HRAS, NRAS, KRAS) selectively modulates cell death pathways triggered by cytotoxic stimuli in rhabdomyosarcoma RMS13 cells. In conclusion, our discovery of an increased resistance to oxidative stress imposed by oncogenic RAS mutants in RMS13 cells has important implications for the development of targeted therapies for rhabdomyosarcoma (RMS).
References
Ref 1 Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death. Front Oncol. 2015 Jun 22;5:131. doi: 10.3389/fonc.2015.00131. eCollection 2015.