Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0219)
Name
Nortriptyline hydrochloride
Synonyms
Nortriptyline hydrochloride; 894-71-3; Nortriptyline Hcl; Pamelor; Desmethylamitriptyline hydrochloride; Allegron; Acetexa; Altilev; Nortriptyline (hydrochloride); Nortrilen; Aventyl hydrochloride; Sensival; Aventyl allegron; Ateben hydrochloride; Nortab hydrochloride; Vividyl; Nortriptylin hydrochloride; Lilly 38489; Noramitriptyline hydrochloride; Nortriptyline monohydrochloride; Norzepine; NSC-169453; 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine Hydrochloride; MLS000069673; 00FN6IH15D; DTXSID2045109; Nortriptyline.HCl; N 7048; SMR000058486; Pamelor hydrochloride; 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-, hydrochloride; Nortriptylene hydrochloride; 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine hydrochloride; WLN: L C676 BY&T&J BU3M1 &GH; NSC78248; NORTRIPTYLINEHYDROCHLORIDE; NSC169453; SR-01000000223; CAS-894-71-3; MFCD00058024; UNII-00FN6IH15D; 5-[3-(Methylamino)propylidene]dibenzo[a,5]diene hydrochloride; (2)10,d]cycloheptene-.delta.5.gamma.-propylamine, hydrochloride; 5-[(3-(Methylamino)propylidene]-10,d]cycloheptene hydrochloride; 5H-Dibenzo[a,.gamma.-propylamine, 10,11-dihydro-N-methyl-, hydrochloride; 5H-Dibenzo[a,.gamma.-propylamine, 10-11-dihydro-N-methyl-, hydrochloride; 1-Propanamine,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-, hydrochloride; Desitriptyline HCl; Prestwick_366; EINECS 212-973-0; Pamelor (TN); NSC 78248; NSC 169453; CPD000058486; ELF-101 hydrochloride; EN-7048 hydrochloride; Nortriptyline hydrochloride [USAN:USP:JAN]; Opera_ID_1915; SCHEMBL41329; MLS001077267; MLS002222206; MLS006010656; CHEBI:7641; CHEMBL1201156; DTXCID0025109; REGID_for_CID_441358; SHAYBENGXDALFF-UHFFFAOYSA-N; HMS1568D10; Nortriptyline hydrochloride- Bio-X; HY-B1417; Nortriptyline for system suitability; Tox21_110048; Tox21_500868; NSC-78248; s3698; 5-(3-(Methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)diene hydrochloride; AKOS015889095; CCG-212718; CS-4913; KS-1306; LP00868; NC00522; Nortriptyline.HCl, 1mg/ml in Methanol; 10,11-Dihydro-5-(N-methyl-3-aminopropylidene)-5H-dibenzo[a,d]cycloheptene Hydrochloride; 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene hydrochloride; NORTRIPTYLINE HYDROCHLORIDE [MI]; NCGC00014483-01; NCGC00094192-01; NCGC00094192-02; NCGC00261553-01; NORTRIPTYLINE HYDROCHLORIDE [JAN]; 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[ a,d]cyclohepten-5-ylidene)-N-methyl-, hydrochloride; 10,11-Dihydro-N-methyl-5H-dibenzo(a,d)cycloheptene-delta(sup 5,gamma)-propylamine hydrochloride; BN164160; NORTRIPTYLINE HYDROCHLORIDE [HSDB]; NORTRIPTYLINE HYDROCHLORIDE [USAN]; NORTRIPTYLINE HYDROCHLORIDE [MART.]; NORTRIPTYLINE HYDROCHLORIDE [VANDF]; NORTRIPTYLINE HYDROCHLORIDE [USP-RS]; NORTRIPTYLINE HYDROCHLORIDE [WHO-DD]; EU-0100868; FT-0673146; FT-0673147; N0957; Nortriptyline hydrochloride (JP17/USP/INN); EN300-26665; D00816; F19641; N 7261; NORTRIPTYLINE HYDROCHLORIDE [ORANGE BOOK]; NORTRIPTYLINE HYDROCHLORIDE [EP MONOGRAPH]; NORTRIPTYLINE HYDROCHLORIDE [USP MONOGRAPH]; Nortriptyline hydrochloride, >=98% (TLC), powder; SR-01000000223-2; SR-01000000223-7; W-109609; Q27231345; Z227834786; Nortriptyline Hydrochloride 1.0 mg/ml in Methanol (as free base); Nortriptyline hydrochloride, British Pharmacopoeia (BP) Reference Standard; Nortriptyline hydrochloride, European Pharmacopoeia (EP) Reference Standard; 3-(10,11-2H-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methyl-1-propanaminium chloride; 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-aminehydrochloride; Nortriptyline for system suitability, European Pharmacopoeia (EP) Reference Standard; Nortriptyline hydrochloride, United States Pharmacopeia (USP) Reference Standard; 10,11-DIHYDRO-N-METHYL-5H-DIBENZO(A,D)CYCLOHEPTENE-D(SUP5,.GAMMA.)-PROPYLAMINE HYDROCHLORIDE; 1001637-77-9; 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10-11-dihydro-N-methyl-, hydrochloride; methyl(3-{tricyclo[9.4.0.0,3,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}propyl)amine hydrochloride

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Structure
3D MOL
2D MOL
Formula
C19H22ClN
IUPAC Name
N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine;hydrochloride
Canonical SMILES
CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
InChI
InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H
InChIKey
SHAYBENGXDALFF-UHFFFAOYSA-N
PubChem CID
441358
Full List of Ferroptosis Target Related to This Drug
Cystine/glutamate transporter (SLC7A11)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Lung cancer ICD-11: 2C25
 Disease Info 
Responsed Regulator RNA-binding motif, single-stranded-interacting protein 1 (RBMS1) Suppressor
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model A-549 cells Lung adenocarcinoma Homo sapiens CVCL_0023
NCI-H1299 cells Lung large cell carcinoma Homo sapiens CVCL_0060
HEK-293T cells Normal Homo sapiens CVCL_0063
In Vivo Model
Doxorubicin (Dox)- inducible RBMS1 knockdown stable cells (3 x 106 ) were injected subcutaneously into the abdomen side of 6-week-old BALB/c nude mice (Vital River). Mice were fed either with sucrose water or sucrose water containing 0.1% doxycycline hyclate. H1299 vector, 4 H1299 pLKO.1 RBMS1 and H1299 pLKO.1 RBMS1/SLC7A11 cells (2.5 x 106 ) were injected subcutaneously into the abdomen side of 6-week-old BALB/c nude mice(Vital River). The xenograft tumour formation was monitored using callipers every 3 days.

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Response regulation RBMS1 ablation inhibited the translation of SLC7A11, reduced SLC7A11-mediated cystine uptake, and promoted ferroptosis. Nortriptyline hydrochloride decreased the level of RBMS1, thereby promoting ferroptosis. Importantly, RBMS1 depletion or inhibition by nortriptyline hydrochloride sensitized radioresistant lung cancer cells to radiotherapy.
References
Ref 1 RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11. J Clin Invest. 2021 Nov 15;131(22):e152067. doi: 10.1172/JCI152067.