Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0148)
Name
Sulforaphane
Synonyms
sulforaphane; 4478-93-7; DL-Sulforaphane; 1-Isothiocyanato-4-(methylsulfinyl)butane; D,L-Sulforaphane; Sulforafan; 1-Isothiocyanato-4-(methylsulfinyl)-butane; 1-isothiocyanato-4-methylsulfinylbutane; Butane, 1-isothiocyanato-4-(methylsulfinyl)-; 4-Methylsulfinylbutyl isothiocyanate; (+/-)-sulforaphane; CHEBI:47807; 41684WL1GL; 4-(Methylsulfinyl)Butyl Isothiocyanate; NSC-749790; (S)-1-Isothiocyanato-4-(methylsulfinyl)butane; R,S-Sulforaphane; Sulphoraphane; sulforaphane, (R)-; SFN; C6H11NOS2; CCRIS 7221; Sulforathane; UNII-41684WL1GL; S)-Sulforaphane; CHEMBL48802; SCHEMBL105202; GTPL6569; DTXSID8036732; SULFORAPHANE, (+/-)-; HMS3746M17; BCP31547; 4-Methylsulfinyl butyl isothiocyanate; BDBM50073654; MFCD00198068; NSC749790; s5771; 4-isothiocyanatobutyl methyl sulfoxide; AKOS006282481; CS-7809; NSC 749790; 4-(Methylsulfinyl)-butyl isothiocyanate; SULFORAPHANE (+/-)-FORM [MI]; 1-isothiocyanato-4-methylsulfinyl-butane; AC-34421; HY-13755; 1-Isothiocyanato-4-(methylsulfinyl)butane #; FT-0674748; FT-0674749; FT-0674750; FT-0674751; U0142; F17072; A912495; Q424489; DL-Sulforaphane, >=90% (HPLC), synthetic, liquid; Q-100160; BRD-A58955223-001-02-0; ISOTHIOCYANIC ACID, 4-(METHYLSULFINYL)BUTYL ESTER; Z1198151975; (R)-Sulforaphane;(-)-Sulforaphane;4-Methylsulfinylbutyl isothiocyanate

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Structure
Formula
C6H11NOS2
IUPAC Name
1-isothiocyanato-4-methylsulfinylbutane
Canonical SMILES
CS(=O)CCCCN=C=S
InChI
InChI=1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
InChIKey
SUVMJBTUFCVSAD-UHFFFAOYSA-N
PubChem CID
5350
Full List of Ferroptosis Target Related to This Drug
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Acute myeloid leukaemia ICD-11: 2A60
 Disease Info 
Pathway Response Glutathione metabolism hsa00480
Fatty acid metabolism hsa01212
Apoptosis hsa04210
Cell Process Cell ferroptosis
Cell proliferation
Cell apoptosis
In Vitro Model U-937 cells Adult acute monocytic leukemia Homo sapiens CVCL_0007
MV4-11 cells Childhood acute monocytic leukemia Homo sapiens CVCL_0064
Response regulation Sulforaphane triggers different types of PCD in a concentration-dependent manner on the two tested acute myeloid leukemia cell lines. Deepening the molecular mechanisms on U-937 cells, we discovered that at lower concentrations, SFN induces apoptosis; at higher concentrations, SFN elicits ferroptosis, characterized by the depletion of intracellular GSH, the downregulation of GPX4 protein expression, and lipid peroxidation.
Cystine/glutamate transporter (SLC7A11)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [2]
Target for Ferroptosis Suppressor
Responsed Disease Lung cancer ICD-11: 2C25
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Glutathione metabolism hsa00480
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model H69 cells Normal Homo sapiens CVCL_8121
NCI-H82 cells Lung small cell carcinoma Homo sapiens CVCL_1591
H69AR cells Lung small cell carcinoma Homo sapiens CVCL_3513
Response regulation Sulforaphane (SFN)-induced cell death was mediated via ferroptosis and inhibition of the mRNA and protein expression levels of SLC7A11 in small-cell lung cancer (SCLC) cells. The anticancer effects of SFN may provide novel options for SCLC treatment.
References
Ref 1 Discovery of Sulforaphane as an Inducer of Ferroptosis in U-937 Leukemia Cells: Expanding Its Anticancer Potential. Cancers (Basel). 2021 Dec 24;14(1):76. doi: 10.3390/cancers14010076.
Ref 2 Effective ferroptotic small-cell lung cancer cell death from SLC7A11 inhibition by sulforaphane. Oncol Lett. 2021 Jan;21(1):71. doi: 10.3892/ol.2020.12332. Epub 2020 Nov 25.