Ferroptosis-centered Drug Response Information
General Information of the Drug (ID: ferrodrug0118)
| Name |
Caryophyllene
|
||||
|---|---|---|---|---|---|
| Synonyms |
Isocaryophyllene; Caryophyllene; 118-65-0; (-)-ISOCARYOPHYLLENE; Cis-caryophyllene; gamma-caryophyllene; NRY8I0KNIR; UNII-NRY8I0KNIR; 87-44-5; Isocaryophyllene (80per cent); (1R,4Z,9S)-4,11,11-trimethyl-8-methylidenebicyclo[7.2.0]undec-4-ene; EINECS 204-267-6; CHEBI:5993; beta-Caryophyllen; DTXSID10881246; CARYOPHYLLENE ISOCARYOPHYLLENE; Bicyclo(7.2.0)undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R,4Z,9S)-; g-Caryophyllene; E-Caryophyllene; EINECS 201-746-1; .gamma.-Caryophyllene; (1R-(1R*,4Z,9S*))-4,11,11-Trimethyl-8-methylenebicyclo(7.2.0)undec-4-ene; (-)-E-Caryophyllene; AI3-36121; .beta.-cis-Caryophyllene; Caryophyllene (VAN); UNII-BHW853AU9H; CCRIS 8094; 2-Methylene-6,10,10-trimethylbicyclo(7.2.0)undec-5-ene; beta-Caryophyllene (natural); -Caryophyllene; ss-Caryophyllene; Bicyclo(7.2.0)undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R,4E,9S)-; 4,11,11-Trimethyl-8-methylenebicyclo(7.2.0)undec-4-ene, (1R-(1R*,4E,9S))-; Bicyclo(7.2.0)undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R-(1R*,4E,9S*))-; 4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene #; CHEMBL448700; (1R,9S,E)-4,11,11-trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene; DTXCID401474828; (-)-Caryophyllene sum of enantiomers; LMPR0103120002; BS-48823; CARYOPHYLLENE ISOCARYOPHYLLENE [MI]; CARYOPHYLLENE, ALPHA + BETA MIXT.; C09691; E75762; Q27106968; (-)-(E)-Caryophyllene;()--caryophyllene;()-trans-Caryophyllene
Click to Show/Hide
|
||||
| Structure |
 |
||||
| Formula |
C15H24
|
||||
| IUPAC Name |
(1R,4Z,9S)-4,11,11-trimethyl-8-methylidenebicyclo[7.2.0]undec-4-ene
|
||||
| Canonical SMILES |
CC1=CCCC(=C)C2CC(C2CC1)(C)C
|
||||
| InChI |
InChI=1S/C15H24/c1-11-6-5-7-12(2)13-10-15(3,4)14(13)9-8-11/h6,13-14H,2,5,7-10H2,1,3-4H3/b11-6-/t13-,14-/m1/s1
|
||||
| InChIKey |
NPNUFJAVOOONJE-FLFDDASRSA-N
|
||||
| PubChem CID | |||||
Full List of Ferroptosis Target Related to This Drug
Nuclear factor erythroid 2-related factor 2 (NFE2L2)
| In total 1 item(s) under this Target | |||||
| Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | ||||
| Target for Ferroptosis | Marker/Suppressor | ||||
| Responsed Disease | Cerebral ischemia | ICD-11: 8B10 | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Cell Process | Cell ferroptosis | ||||
| In Vitro Model | rPAs (Rat primary astrocytes) | ||||
| In Vivo Model |
Rats were anesthetized withisoflurane(2-3% oxygen) and placed in asupine position. And theright common carotid artery (CCA),external carotid artery (ECA), andinternal carotid artery (ICA) were exposed in sequence and separated carefully. Then we ligated the CCA and the ECA in turn, and at the same time, we clamped the internal carotid artery with an arterial clamp. Finally, we inserted a silicone nylon monofilament from the CCA into themiddle cerebral arteryand temporarily fixed it. After 1.5 h ofischemia, the monofilament was taken out and the blood vessels were ligated at theincision. The neck wound was sutured with surgical sutures. Subsequent experiments were performed after 12 h ofreperfusion. In thesham operationrats, except for the absence of the monofilament, the sham operation rats underwent the same surgical procedures as the MCAO/R model rats.
Click to Show/Hide
|
||||
| Response regulation | Our results indicated the critical role of ferroptosis in cerebral ischemia reperfusion injury. For the first time, we showed that the significant neuroprotective effects of b-Caryophyllene (BCP) in attenuating ischemic stroke injury are correlated with ferroptosis regulation, and its mechanism is associated with activation of the NRF2/HO-1 axis. | ||||
Heme oxygenase 1 (HMOX1)
| In total 1 item(s) under this Target | |||||
| Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | ||||
| Target for Ferroptosis | Suppressor | ||||
| Responsed Disease | Cerebral ischemia | ICD-11: 8B10 | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Cell Process | Cell ferroptosis | ||||
| In Vitro Model | rPAs (Rat primary astrocytes) | ||||
| In Vivo Model |
Rats were anesthetized withisoflurane(2-3% oxygen) and placed in asupine position. And theright common carotid artery (CCA),external carotid artery (ECA), andinternal carotid artery (ICA) were exposed in sequence and separated carefully. Then we ligated the CCA and the ECA in turn, and at the same time, we clamped the internal carotid artery with an arterial clamp. Finally, we inserted a silicone nylon monofilament from the CCA into themiddle cerebral arteryand temporarily fixed it. After 1.5 h ofischemia, the monofilament was taken out and the blood vessels were ligated at theincision. The neck wound was sutured with surgical sutures. Subsequent experiments were performed after 12 h ofreperfusion. In thesham operationrats, except for the absence of the monofilament, the sham operation rats underwent the same surgical procedures as the MCAO/R model rats.
Click to Show/Hide
|
||||
| Response regulation | Our results indicated the critical role of ferroptosis in cerebral ischemia reperfusion injury. For the first time, we showed that the significant neuroprotective effects of b-Caryophyllene (BCP) in attenuating ischemic stroke injury are correlated with ferroptosis regulation, and its mechanism is associated with activation of the NRF2/HO-1 axis. | ||||