Ferroptosis-centered Drug Response Information
General Information of the Drug (ID: ferrodrug0022)
Name |
Bisphenol A
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Synonyms |
Bisphenol A; 80-05-7; 2,2-Bis(4-hydroxyphenyl)propane; 4,4'-Isopropylidenediphenol; Diphenylolpropane; 4,4'-Bisphenol A; Bisphenol; Diano; Bisphenol-A; 4,4'-(propane-2,2-diyl)diphenol; Biphenol A; Parabis A; 2,2-Bis(p-hydroxyphenyl)propane; DIAN; p,p'-Isopropylidenebisphenol; Rikabanol; p,p'-Bisphenol A; Bisferol A; 2,2-Di(4-phenylol)propane; Ipognox 88; Pluracol 245; p,p'-Dihydroxydiphenylpropane; Phenol, 4,4'-(1-methylethylidene)bis-; 4,4'-Dihydroxydiphenylpropane; Ucar bisphenol A; 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol; Dimethylmethylene-p,p'-diphenol; p,p'-Isopropylidenediphenol; BPA; Bis(4-hydroxyphenyl)propane; Ucar bisphenol HP; 4,4'-(1-Methylethylidene)bisphenol; 2,2-Di(4-hydroxyphenyl)propane; 4,4'-Isopropylidene diphenol; 2,2-Bis(hydroxyphenyl)propane; p,p'-Dihydroxydiphenyldimethylmethane; 4,4'-Isopropylidenebisphenol; Bis(4-hydroxyphenyl)dimethylmethane; Isopropylidenebis(4-hydroxybenzene); Bis(4-hydroxyphenyl) dimethylmethane; 4,4'-Dihydroxydiphenyldimethylmethane; 2,2-Bis-4'-hydroxyfenylpropan; 4,4'-Dihydroxy-2,2-diphenylpropane; Phenol, 4,4'-isopropylidenedi-; 2,2-(4,4'-Dihydroxydiphenyl)propane; 4,4'-propane-2,2-diyldiphenol; Phenol, (1-methylethylidene)bis-; 4,4' Isopropylidinediphenol; NCI-C50635; Dimethylbis(p-hydroxyphenyl)methane; 2,2-Bis(4'-hydroxyphenyl)propane; beta-di-p-hydroxyphenylpropane; Dimethyl bis(p-hydroxyphenyl)methane; Bisphenol A.; 4,4'-Dihydroxydiphenyl-2,2-propane; Bis(p-hydroxyphenyl)propane; CCRIS 95; Phenol, 4,4'-dimethylmethylenedi-; 2,2-Bis (4-hydroxyphenol) propane; Propane, 2,2-bis(p-hydroxyphenyl)-; 4,4'-Dimethylmethylenediphenol; HSDB 513; 4-[1-(4-hydroxyphenyl)-1-methylethyl]phenol; beta,beta'-Bis(p-hydroxyphenyl)propane; DTXSID7020182; 4,4-ISOPROPYLIDENEDIPHENOL; NSC 1767; EINECS 201-245-8; 4,4[-Isopropylidenediphenol; 4,4'-Dihydroxdiphenylpropane; UNII-MLT3645I99; BRN 1107700; 4,4'-Isopropylidenebis[phenol]; Bisphenol A (BPA); CHEBI:33216; 4,4'-(1-Methylethane-1,1-diyl)diphenol; AI3-04009; 2,2-bis[4-Hydroxyphenyl]propane; MLT3645I99; 2, 2-Bis(4-hydroxyphenyl)propane; 2,2-bis(4-hydroxyphenyl) propane; NSC-1767; MFCD00002366; 2,2-(4,4-Dihydroxydiphenyl)propane; 25766-59-0; beta,beta-di-(p-hydroxyphenyl)propane; DTXCID30182; BPA 157; EC 201-245-8; di-2,2-(4-Hydroxyphenyl)propane; 2,2'-Bis(4-hydroxyphenyl)propane; 4,4'-ISOPROPYLIDENEDIPHENOL (BISPHENOL A); 4-06-00-06717 (Beilstein Handbook Reference); 4,2-propane; 2,2-di-(4'-Hydroxyphenyl)-propane; 4,2-diphenylpropane; 2,2-Bis(4,4'-hydroxyphenyl)propane; NCGC00090952-07; BISPHENOL-A-2,2',6,6'-D4; .beta.,.beta.'-Bis(p-hydroxyphenyl)propane; BISPHENOL-A-3,3',5,5'-D4; Phenol,4'-isopropylidenedi-; 27100-33-0; Bisphenol-A-2,2',3,3',5,5',6,6'-D8; BISPHENOL A (USP-RS); BISPHENOL A [USP-RS]; Phenol,4'-dimethylmethylenedi-; 2,4'-Dihydroxydiphenyl)propane; Bisferol A [Czech]; WLN: QR DX1&1&R DQ; Propane,2-bis(p-hydroxyphenyl)-; .beta.-Di-(p-hydroxyphenyl)propane; Phenol,4'-(1-methylethylidene)bis-; 4,4'-ISOPROPYLIDENEBIS(PHENOL); CAS-80-05-7; 347841-41-2; 102438-62-0; bisphenol A, sodium salt; bisphenol A, disodium salt; 2,2-Bis-4'-hydroxyfenylpropan [Czech]; bis-phenol-a; bis-phenol A; Bis Phenol A; Millad HBPA; 2OH; 4,4'-ISOPROPYLIDENE-DIPHENOL; bis(4-hyd roxyphenyl) dimethylmethane; 4,4'-bisphenol-A; Bisphenol A, 97%; 2e2r; 2p7g; 4, 4'-Bisphenol A; BISPHENOL A [MI]; Bisphenol A, >=99%; 4,4'-isopropylidendiphenol; BISPHENOL A [HSDB]; Bisphenol a(ring 13c12); HIDORIN F 285; BIDD:PXR0120; Oprea1_215541; p, p'-Isopropylidenediphenol; SCHEMBL15062; bis(4-hydroxyphenyl)-propane; MLS001055461; BIDD:ER0208; 4,4'-Isopropylidenedi-Phenol; p, p'-Dihydroxydiphenylpropane; (1-methylethylidene)bis-Phenol; 2, 2-Di(4-phenylol)propane; 4,4'-Isopropylidenediphenol B; CHEMBL418971; GTPL7865; 4, 4'-Dihydroxydiphenylpropane; 2, 2-Bis(hydroxyphenyl)propane; .beta.-di-p-hydroxyphenylpropane; 4,4'-Dimethylmethylenedi-Phenol; 4,4'-Isopropylidendiphenol dust; BDBM29608; beta-Di-(p-hydroxyphenyl)propane; BPA 154; NSC1767; 2,2-bis(p-hydroxyphenyl)-propane; HMS2866B07; HMS3749E11; KUC105370N; 2,2-di(p-hydroxy-phenyl-)propane; 4,4'-Isopropylidenediphenol, 8CI; 2,2-bis-(p-hydroxyphenyl)-propane; CS-B1737; NSC17959; 2,2-bis-(4-hydroxy phenyl)propane; 2,2-bis-(4-hydroxyphenyl) propane; 2,2-bis-(4-hydroxyphenyl)-propane; Tox21_202992; Tox21_400088; 4,4?-(1-Methylethylidene)bisphenol; BBL010647; dimethyl bis(p-hydroxyphenyl)methane; KSC-7-199; NSC-17959; s6007; STK801675; 2,2-bis-(4- hydroxyphenyl)-propane; p, p'-Dihydroxydiphenyldimethylmethane; 4,4'-(1-methylethylidene)bis-phenol; 4,4'-dihydroxy diphenyl-2,2-propane; AKOS000119022; 4, 4'-Dihydroxydiphenyl-2,2-propane; 4, 4'-Dihydroxydiphenyldimethylmethane; CCG-214370; DB06973; beta, beta'-Bis(p-hydroxyphenyl)propane; UPCMLD0ENAT5883875:001; NCGC00090952-01; NCGC00090952-02; NCGC00090952-03; NCGC00090952-04; NCGC00090952-05; NCGC00090952-06; NCGC00090952-08; NCGC00090952-09; NCGC00260537-01; HY-18260; SMR000315090; VS-02603; 4,4'-(1-Methylethylidene)bisphenol, 9CI; 4,4'-ISOPROPYLIDENEDIPHENOL [INCI]; Bisphenol A 100 microg/mL in Acetonitrile; 1,1'-(1-Methylethylidene)bisphenylol, 9CI; B0494; FT-0609178; FT-0663365; FT-0663366; FT-0663367; 872 - Bisphenols in 3% aqueous acetic acid; EN300-19430; Bisphenol A 2,2-Bis(4-hydroxyphenyl) propane; D77313; 4,4'-Isopropylidenediphenol, analytical standard; 4,4'-ISOPROPYLIDENEDIPHENOL; BISPHENOL A; Bisphenol A-d14 100 Amicrog/mL in Acetonitrile; A839823; AE-848/01247026; Q271980; SR-01000596928; SR-01000596928-1; 4,4'-Isopropylidenediphenol C12-15 alcohol phosphite; BRD-K41494493-001-04-7; Bisphenol A, certified reference material, TraceCERT(R); F1284-0895; Z104473824; Bisphenol A, United States Pharmacopeia (USP) Reference Standard; 96152-48-6; InChI=1/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H
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Status |
Investigative
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Drug Type |
Small molecular drug
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Structure |
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Formula |
C15H16O2
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IUPAC Name |
4-[2-(4-hydroxyphenyl)propan-2-yl]phenol
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Canonical SMILES |
CC(C)(C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
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InChI |
InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3
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InChIKey |
IISBACLAFKSPIT-UHFFFAOYSA-N
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PubChem CID | |||||
TTD Drug ID |
Full List of Ferroptosis Target Related to This Drug
Ferritin heavy chain (FTH1)
In total 1 item(s) under this Target | |||||
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | ||||
Target for Ferroptosis | Marker/Suppressor | ||||
Responsed Disease | Renal dysfunction | ICD-11: GB6Z | |||
Responsed Regulator | Serine/threonine-protein kinase ULK1 (ULK1) | Driver | |||
Pathway Response | Fatty acid metabolism | hsa01212 | |||
Ferroptosis | hsa04216 | ||||
Autophagy | hsa04140 | ||||
Cell Process | Cell ferroptosis | ||||
Cell autophagy | |||||
Cell proliferation | |||||
In Vitro Model | TCMK-1 cells | Normal | Mus musculus | CVCL_2772 | |
In Vivo Model |
Balb/c mice aged 6-8 weeks were purchased from Liaoning Changsheng biotechnology co., Ltd. (Benxi, China). All animal experiments comply with the requirements of the Institutional Animal Care and Use Committee (IACUC) of Jilin University. The mice were housed in separate cages and given enough food and drinking water during the conditions of a 12-h light and dark cycle. The establishment of animal models is as previously described.
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Response regulation | Renal dysfunction and renal tubular epithelial damage induced by Bisphenol A (BPA) are linked to ferroptosis, which depends on the activation of ferritinophagy through AMPK-mTOR- ULK1 axis. These findings revealed that after BPA treatment, FTH was significantly reduced and iron was accumulated. | ||||