General Information of the Drug (ID: ferrodrug0022)
Name
Bisphenol A
Synonyms
Bisphenol A; 80-05-7; 2,2-Bis(4-hydroxyphenyl)propane; 4,4'-Isopropylidenediphenol; Diphenylolpropane; 4,4'-Bisphenol A; Bisphenol; Diano; Bisphenol-A; 4,4'-(propane-2,2-diyl)diphenol; Biphenol A; Parabis A; 2,2-Bis(p-hydroxyphenyl)propane; DIAN; p,p'-Isopropylidenebisphenol; Rikabanol; p,p'-Bisphenol A; Bisferol A; 2,2-Di(4-phenylol)propane; Ipognox 88; Pluracol 245; p,p'-Dihydroxydiphenylpropane; Phenol, 4,4'-(1-methylethylidene)bis-; 4,4'-Dihydroxydiphenylpropane; Ucar bisphenol A; 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol; Dimethylmethylene-p,p'-diphenol; p,p'-Isopropylidenediphenol; BPA; Bis(4-hydroxyphenyl)propane; Ucar bisphenol HP; 4,4'-(1-Methylethylidene)bisphenol; 2,2-Di(4-hydroxyphenyl)propane; 4,4'-Isopropylidene diphenol; 2,2-Bis(hydroxyphenyl)propane; p,p'-Dihydroxydiphenyldimethylmethane; 4,4'-Isopropylidenebisphenol; Bis(4-hydroxyphenyl)dimethylmethane; Isopropylidenebis(4-hydroxybenzene); Bis(4-hydroxyphenyl) dimethylmethane; 4,4'-Dihydroxydiphenyldimethylmethane; 2,2-Bis-4'-hydroxyfenylpropan; 4,4'-Dihydroxy-2,2-diphenylpropane; Phenol, 4,4'-isopropylidenedi-; 2,2-(4,4'-Dihydroxydiphenyl)propane; 4,4'-propane-2,2-diyldiphenol; Phenol, (1-methylethylidene)bis-; 4,4' Isopropylidinediphenol; NCI-C50635; Dimethylbis(p-hydroxyphenyl)methane; 2,2-Bis(4'-hydroxyphenyl)propane; beta-di-p-hydroxyphenylpropane; Dimethyl bis(p-hydroxyphenyl)methane; Bisphenol A.; 4,4'-Dihydroxydiphenyl-2,2-propane; Bis(p-hydroxyphenyl)propane; CCRIS 95; Phenol, 4,4'-dimethylmethylenedi-; 2,2-Bis (4-hydroxyphenol) propane; Propane, 2,2-bis(p-hydroxyphenyl)-; 4,4'-Dimethylmethylenediphenol; HSDB 513; 4-[1-(4-hydroxyphenyl)-1-methylethyl]phenol; beta,beta'-Bis(p-hydroxyphenyl)propane; DTXSID7020182; 4,4-ISOPROPYLIDENEDIPHENOL; NSC 1767; EINECS 201-245-8; 4,4[-Isopropylidenediphenol; 4,4'-Dihydroxdiphenylpropane; UNII-MLT3645I99; BRN 1107700; 4,4'-Isopropylidenebis[phenol]; Bisphenol A (BPA); CHEBI:33216; 4,4'-(1-Methylethane-1,1-diyl)diphenol; AI3-04009; 2,2-bis[4-Hydroxyphenyl]propane; MLT3645I99; 2, 2-Bis(4-hydroxyphenyl)propane; 2,2-bis(4-hydroxyphenyl) propane; NSC-1767; MFCD00002366; 2,2-(4,4-Dihydroxydiphenyl)propane; 25766-59-0; beta,beta-di-(p-hydroxyphenyl)propane; DTXCID30182; BPA 157; EC 201-245-8; di-2,2-(4-Hydroxyphenyl)propane; 2,2'-Bis(4-hydroxyphenyl)propane; 4,4'-ISOPROPYLIDENEDIPHENOL (BISPHENOL A); 4-06-00-06717 (Beilstein Handbook Reference); 4,2-propane; 2,2-di-(4'-Hydroxyphenyl)-propane; 4,2-diphenylpropane; 2,2-Bis(4,4'-hydroxyphenyl)propane; NCGC00090952-07; BISPHENOL-A-2,2',6,6'-D4; .beta.,.beta.'-Bis(p-hydroxyphenyl)propane; BISPHENOL-A-3,3',5,5'-D4; Phenol,4'-isopropylidenedi-; 27100-33-0; Bisphenol-A-2,2',3,3',5,5',6,6'-D8; BISPHENOL A (USP-RS); BISPHENOL A [USP-RS]; Phenol,4'-dimethylmethylenedi-; 2,4'-Dihydroxydiphenyl)propane; Bisferol A [Czech]; WLN: QR DX1&1&R DQ; Propane,2-bis(p-hydroxyphenyl)-; .beta.-Di-(p-hydroxyphenyl)propane; Phenol,4'-(1-methylethylidene)bis-; 4,4'-ISOPROPYLIDENEBIS(PHENOL); CAS-80-05-7; 347841-41-2; 102438-62-0; bisphenol A, sodium salt; bisphenol A, disodium salt; 2,2-Bis-4'-hydroxyfenylpropan [Czech]; bis-phenol-a; bis-phenol A; Bis Phenol A; Millad HBPA; 2OH; 4,4'-ISOPROPYLIDENE-DIPHENOL; bis(4-hyd roxyphenyl) dimethylmethane; 4,4'-bisphenol-A; Bisphenol A, 97%; 2e2r; 2p7g; 4, 4'-Bisphenol A; BISPHENOL A [MI]; Bisphenol A, >=99%; 4,4'-isopropylidendiphenol; BISPHENOL A [HSDB]; Bisphenol a(ring 13c12); HIDORIN F 285; BIDD:PXR0120; Oprea1_215541; p, p'-Isopropylidenediphenol; SCHEMBL15062; bis(4-hydroxyphenyl)-propane; MLS001055461; BIDD:ER0208; 4,4'-Isopropylidenedi-Phenol; p, p'-Dihydroxydiphenylpropane; (1-methylethylidene)bis-Phenol; 2, 2-Di(4-phenylol)propane; 4,4'-Isopropylidenediphenol B; CHEMBL418971; GTPL7865; 4, 4'-Dihydroxydiphenylpropane; 2, 2-Bis(hydroxyphenyl)propane; .beta.-di-p-hydroxyphenylpropane; 4,4'-Dimethylmethylenedi-Phenol; 4,4'-Isopropylidendiphenol dust; BDBM29608; beta-Di-(p-hydroxyphenyl)propane; BPA 154; NSC1767; 2,2-bis(p-hydroxyphenyl)-propane; HMS2866B07; HMS3749E11; KUC105370N; 2,2-di(p-hydroxy-phenyl-)propane; 4,4'-Isopropylidenediphenol, 8CI; 2,2-bis-(p-hydroxyphenyl)-propane; CS-B1737; NSC17959; 2,2-bis-(4-hydroxy phenyl)propane; 2,2-bis-(4-hydroxyphenyl) propane; 2,2-bis-(4-hydroxyphenyl)-propane; Tox21_202992; Tox21_400088; 4,4?-(1-Methylethylidene)bisphenol; BBL010647; dimethyl bis(p-hydroxyphenyl)methane; KSC-7-199; NSC-17959; s6007; STK801675; 2,2-bis-(4- hydroxyphenyl)-propane; p, p'-Dihydroxydiphenyldimethylmethane; 4,4'-(1-methylethylidene)bis-phenol; 4,4'-dihydroxy diphenyl-2,2-propane; AKOS000119022; 4, 4'-Dihydroxydiphenyl-2,2-propane; 4, 4'-Dihydroxydiphenyldimethylmethane; CCG-214370; DB06973; beta, beta'-Bis(p-hydroxyphenyl)propane; UPCMLD0ENAT5883875:001; NCGC00090952-01; NCGC00090952-02; NCGC00090952-03; NCGC00090952-04; NCGC00090952-05; NCGC00090952-06; NCGC00090952-08; NCGC00090952-09; NCGC00260537-01; HY-18260; SMR000315090; VS-02603; 4,4'-(1-Methylethylidene)bisphenol, 9CI; 4,4'-ISOPROPYLIDENEDIPHENOL [INCI]; Bisphenol A 100 microg/mL in Acetonitrile; 1,1'-(1-Methylethylidene)bisphenylol, 9CI; B0494; FT-0609178; FT-0663365; FT-0663366; FT-0663367; 872 - Bisphenols in 3% aqueous acetic acid; EN300-19430; Bisphenol A 2,2-Bis(4-hydroxyphenyl) propane; D77313; 4,4'-Isopropylidenediphenol, analytical standard; 4,4'-ISOPROPYLIDENEDIPHENOL; BISPHENOL A; Bisphenol A-d14 100 Amicrog/mL in Acetonitrile; A839823; AE-848/01247026; Q271980; SR-01000596928; SR-01000596928-1; 4,4'-Isopropylidenediphenol C12-15 alcohol phosphite; BRD-K41494493-001-04-7; Bisphenol A, certified reference material, TraceCERT(R); F1284-0895; Z104473824; Bisphenol A, United States Pharmacopeia (USP) Reference Standard; 96152-48-6; InChI=1/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H

    Click to Show/Hide
Status
Investigative
Drug Type
Small molecular drug
Structure
Formula
C15H16O2
IUPAC Name
4-[2-(4-hydroxyphenyl)propan-2-yl]phenol
Canonical SMILES
CC(C)(C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
InChI
InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3
InChIKey
IISBACLAFKSPIT-UHFFFAOYSA-N
PubChem CID
6623
TTD Drug ID
D02RQP
Full List of Ferroptosis Target Related to This Drug
Ferritin heavy chain (FTH1)
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Marker/Suppressor
Responsed Disease Renal dysfunction ICD-11: GB6Z
Responsed Regulator Serine/threonine-protein kinase ULK1 (ULK1) Driver
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Autophagy hsa04140
Cell Process Cell ferroptosis
Cell autophagy
Cell proliferation
In Vitro Model TCMK-1 cells Normal Mus musculus CVCL_2772
In Vivo Model
Balb/c mice aged 6-8 weeks were purchased from Liaoning Changsheng biotechnology co., Ltd. (Benxi, China). All animal experiments comply with the requirements of the Institutional Animal Care and Use Committee (IACUC) of Jilin University. The mice were housed in separate cages and given enough food and drinking water during the conditions of a 12-h light and dark cycle. The establishment of animal models is as previously described.

    Click to Show/Hide
Response regulation Renal dysfunction and renal tubular epithelial damage induced by Bisphenol A (BPA) are linked to ferroptosis, which depends on the activation of ferritinophagy through AMPK-mTOR- ULK1 axis. These findings revealed that after BPA treatment, FTH was significantly reduced and iron was accumulated.
References
Ref 1 Ferritinophagy is involved in Bisphenol A-induced ferroptosis of renal tubular epithelial cells through the activation of the AMPK-mTOR-ULK1 pathway. Food Chem Toxicol. 2022 May;163:112909. doi: 10.1016/j.fct.2022.112909. Epub 2022 Mar 12.