General Information of the Disease (ID: DIS00133)
Name
Renal dysfunction
ICD
ICD-11: GB6Z
Full List of Target(s) of This Ferroptosis-centered Disease
Ferritin heavy chain (FTH1)
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Target for Ferroptosis Marker/Suppressor
Responsed Disease Renal dysfunction [ICD-11: GB6Z]
Responsed Drug Bisphenol A Investigative
Responsed Regulator Serine/threonine-protein kinase ULK1 (ULK1) Driver
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Autophagy hsa04140
Cell Process Cell ferroptosis
Cell autophagy
Cell proliferation
In Vitro Model TCMK-1 cells Normal Mus musculus CVCL_2772
In Vivo Model
Balb/c mice aged 6-8 weeks were purchased from Liaoning Changsheng biotechnology co., Ltd. (Benxi, China). All animal experiments comply with the requirements of the Institutional Animal Care and Use Committee (IACUC) of Jilin University. The mice were housed in separate cages and given enough food and drinking water during the conditions of a 12-h light and dark cycle. The establishment of animal models is as previously described.

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Response regulation Renal dysfunction and renal tubular epithelial damage induced by Bisphenol A (BPA) are linked to ferroptosis, which depends on the activation of ferritinophagy through AMPK-mTOR- ULK1 axis. These findings revealed that after BPA treatment, FTH was significantly reduced and iron was accumulated.
References
Ref 1 Ferritinophagy is involved in Bisphenol A-induced ferroptosis of renal tubular epithelial cells through the activation of the AMPK-mTOR-ULK1 pathway. Food Chem Toxicol. 2022 May;163:112909. doi: 10.1016/j.fct.2022.112909. Epub 2022 Mar 12.