Ferroptosis-centered Disease Response Information
General Information of the Disease (ID: DIS00133)
| Name |
Renal dysfunction
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| ICD |
ICD-11: GB6Z
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Full List of Target(s) of This Ferroptosis-centered Disease
Ferritin heavy chain (FTH1)
| In total 1 item(s) under this target | |||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target | [1] | ||||
| Target for Ferroptosis | Marker/Suppressor | ||||
| Responsed Disease | Renal dysfunction [ICD-11: GB6Z] | ||||
| Responsed Drug | Bisphenol A | Investigative | |||
| Responsed Regulator | Serine/threonine-protein kinase ULK1 (ULK1) | Driver | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Ferroptosis | hsa04216 | ||||
| Autophagy | hsa04140 | ||||
| Cell Process | Cell ferroptosis | ||||
| Cell autophagy | |||||
| Cell proliferation | |||||
| In Vitro Model | TCMK-1 cells | Normal | Mus musculus | CVCL_2772 | |
| In Vivo Model |
Balb/c mice aged 6-8 weeks were purchased from Liaoning Changsheng biotechnology co., Ltd. (Benxi, China). All animal experiments comply with the requirements of the Institutional Animal Care and Use Committee (IACUC) of Jilin University. The mice were housed in separate cages and given enough food and drinking water during the conditions of a 12-h light and dark cycle. The establishment of animal models is as previously described.
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| Response regulation | Renal dysfunction and renal tubular epithelial damage induced by Bisphenol A (BPA) are linked to ferroptosis, which depends on the activation of ferritinophagy through AMPK-mTOR- ULK1 axis. These findings revealed that after BPA treatment, FTH was significantly reduced and iron was accumulated. | ||||