Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0001)
Name
Formaldehyde
Synonyms
formaldehyde; formalin; methanal; Paraformaldehyde; 50-00-0; formol; Methylene oxide; Oxomethane; Formic aldehyde; Paraform; Oxymethylene; Methyl aldehyde; Superlysoform; Lysoform; Fannoform; Formalith; Formalina; Methaldehyde; Oxomethylene; Morbicid; Karsan; 30525-89-4; Formaldehyd; Formaline; FYDE; Formaldehyde, gas; Aldeide formica; Aldehyde formique; Oplossingen; Formalin 40; Dormol; Rcra waste number U122; Aldehyd mravenci; Formalin-loesungen; Formalaz; Caswell No. 465; NCI-C02799; CH2O; UN 2209 (formalin); Formaldehyde (gas); UN 1198; Formaline [German]; Formalina [Italian]; Oplossingen [Dutch]; HCHO; CCRIS 315; FORMYL GROUP; HSDB 164; Fordor; NSC 298885; CHEBI:16842; Aldehyd mravenci [Czech]; Aldeide formica [Italian]; AI3-26806; Aldehyde formique [French]; BFV; Formalin-loesungen [German]; Formaldehyd [Czech, Polish]; EPA Pesticide Chemical Code 043001; NSC-298885; Formaldehyde [USP]; Aldehyde formique [ISO-French]; DTXSID7020637; UNII-1HG84L3525; EINECS 200-001-8; UN1198; UN2209; RCRA waste no. U122; 1HG84L3525; EC 200-001-8; Formaldehyde-13C, d2 solution; Formaldehyde (USP); NSC298885; CARBON MONOXIDE (13C; 18O); DSSTox_CID_637; FORMALDEHYDE (IARC); FORMALDEHYDE [IARC]; DSSTox_RID_82549; Paraformic aldehyde; DSSTox_GSID_47796; Formaldehyd (CZECH, POLISH); Aldehyde formique (ISO-French); 63101-50-8; Formaldehido; Veracur; MFCD00003274; MFCD00133991; 35907-63-2; Methan 21; Formic aldehyde; formaidehyde; formaldeyde; formaldhyde; methanon; paraformaldehyd; paraformaldehye; Formadehyde; Formaldehye; Formalinum; Durine; paraformaidehyde; para formaldehyde; paraform-aldehyde; Para-formaldehyde; F-gen; Hyperband (TN); Formalin [JAN]; HCOH; 28 - Formaldehyde; Floguard 1015; Formalin (JP17); CARBON-MONOXIDE; Formaldehyde; Methanal; Hercules 37M6-8; H2CO; WLN: VHH; Formaldehyde [BSI:ISO]; FORMALDEHYDE [II]; FORMALDEHYDE [MI]; Paraformaldehyde (JP17); bmse000256; Epitope ID:116196; FORMALDEHYDE [INCI]; Formaldehyde, 4% in PBS; Formaldehyde, methanol-free; CHEMBL1255; FORMALDEHYDE [VANDF]; Pesticide Code: 043001; BIDD:ER0493; DTXCID30637; GTPL4196; AMY6741; CHEBI:188447; NSC28424; STR00013; Tox21_111160; Tox21_302438; FM 282; AKOS008967440; DB03843; NA 9202; UN 1016; UN 2209; NCGC00255116-01; 53026-80-5; 8013-13-6; BP-21234; E240; Formaldehyde (37per cent w/w aq. soln.); F0622; FT-0626522; FT-0689115; P0018; C00067; D00017; D01494; A827922; Q161210; SR-01000944454; SR-01000944454-1; Q27110014; formaldehyde;formaldehyde [bsi:iso];methanal;formaldehyde (act. 37%);formalin;formaldehyde formaldehyde [bsi:iso] methanal formaldehyde (act. 37%) formalin

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Status
Investigative
Drug Type
Small molecular drug
Structure
Formula
CH2O
IUPAC Name
formaldehyde
Canonical SMILES
C=O
InChI
InChI=1S/CH2O/c1-2/h1H2
InChIKey
WSFSSNUMVMOOMR-UHFFFAOYSA-N
PubChem CID
712
TTD Drug ID
D01KEE
Full List of Ferroptosis Target Related to This Drug
Sodium-coupled neutral amino acid symporter 1 (SLC38A1)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Driver
Responsed Disease Neurotoxicity ICD-11: NE61
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model HT22 cells Normal Mus musculus CVCL_0321
In Vivo Model
Sprague-Dawley (SD, weight: 200-220 g) rats were obtained from Hunan SJA laboratory animal company (Changsha, Hunan, China). SD rats were anaesthetized by sodium pentobarbital (45 mg/kg, i.p.) and secured in a stereotaxic frame. The aseptically cannula was implanted into lateral ventricle according to the following coordinates: AP: -1mm; ML: 2 mm; DV: 4 mm. During experiment, the unilateral ventricle of rats was received 2.5 ul FA (0.1, 1, 10 umol) according to the experiment scheme in vivo.

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Response regulation Formaldehyde (FA)-induced neurotoxicity is implicated in neuronal ferroptosis. FA induced cell death in HT22 cells, and upregulated the ferroptosis-associated genes, including Ptgs2 (prostaglandin-endoperoxide synthase 2), GLS2 (glutaminase 2), solute carrier family 1 member 5 (SLC1A5), and solute carrier family 38 member 1 (SLC38A1) in HT22 cells, indicating the inductive role of FA in the ferroptosis of HT22 cells for the formaldehyde-induced neurotoxicity.
Prostaglandin G/H synthase 2 (PTGS2)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Marker
Responsed Disease Neurotoxicity ICD-11: NE61
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model HT22 cells Normal Mus musculus CVCL_0321
In Vivo Model
Sprague-Dawley (SD, weight: 200-220 g) rats were obtained from Hunan SJA laboratory animal company (Changsha, Hunan, China). SD rats were anaesthetized by sodium pentobarbital (45 mg/kg, i.p.) and secured in a stereotaxic frame. The aseptically cannula was implanted into lateral ventricle according to the following coordinates: AP: -1mm; ML: 2 mm; DV: 4 mm. During experiment, the unilateral ventricle of rats was received 2.5 ul FA (0.1, 1, 10 umol) according to the experiment scheme in vivo.

    Click to Show/Hide
Response regulation Formaldehyde (FA)-induced neurotoxicity is implicated in neuronal ferroptosis. FA induced cell death in HT22 cells, and upregulated the ferroptosis-associated genes, including Ptgs2 (prostaglandin-endoperoxide synthase 2), GLS2 (glutaminase 2), solute carrier family 1 member 5 (SLC1A5), and solute carrier family 38 member 1 (SLC38A1) in HT22 cells, indicating the inductive role of FA in the ferroptosis of HT22 cells for the formaldehyde-induced neurotoxicity.
Neutral amino acid transporter B(0) (SLC1A5)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Driver
Responsed Disease Neurotoxicity ICD-11: NE61
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model HT22 cells Normal Mus musculus CVCL_0321
In Vivo Model
Sprague-Dawley (SD, weight: 200-220 g) rats were obtained from Hunan SJA laboratory animal company (Changsha, Hunan, China). SD rats were anaesthetized by sodium pentobarbital (45 mg/kg, i.p.) and secured in a stereotaxic frame. The aseptically cannula was implanted into lateral ventricle according to the following coordinates: AP: -1mm; ML: 2 mm; DV: 4 mm. During experiment, the unilateral ventricle of rats was received 2.5 ul FA (0.1, 1, 10 umol) according to the experiment scheme in vivo.

    Click to Show/Hide
Response regulation Formaldehyde (FA)-induced neurotoxicity is implicated in neuronal ferroptosis. FA induced cell death in HT22 cells, and upregulated the ferroptosis-associated genes, including Ptgs2 (prostaglandin-endoperoxide synthase 2), GLS2 (glutaminase 2), solute carrier family 1 member 5 (SLC1A5), and solute carrier family 38 member 1 (SLC38A1) in HT22 cells, indicating the inductive role of FA in the ferroptosis of HT22 cells for the formaldehyde-induced neurotoxicity.
Glutaminase liver isoform, mitochondrial (GLS2)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Driver
Responsed Disease Neurotoxicity ICD-11: NE61
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model HT22 cells Normal Mus musculus CVCL_0321
In Vivo Model
Sprague-Dawley (SD, weight: 200-220 g) rats were obtained from Hunan SJA laboratory animal company (Changsha, Hunan, China). SD rats were anaesthetized by sodium pentobarbital (45 mg/kg, i.p.) and secured in a stereotaxic frame. The aseptically cannula was implanted into lateral ventricle according to the following coordinates: AP: -1mm; ML: 2 mm; DV: 4 mm. During experiment, the unilateral ventricle of rats was received 2.5 ul FA (0.1, 1, 10 umol) according to the experiment scheme in vivo.

    Click to Show/Hide
Response regulation Formaldehyde (FA)-induced neurotoxicity is implicated in neuronal ferroptosis. FA induced cell death in HT22 cells, and upregulated the ferroptosis-associated genes, including Ptgs2 (prostaglandin-endoperoxide synthase 2), GLS2 (glutaminase 2), solute carrier family 1 member 5 (SLC1A5), and solute carrier family 38 member 1 (SLC38A1) in HT22 cells, indicating the inductive role of FA in the ferroptosis of HT22 cells for the formaldehyde-induced neurotoxicity.
References
Ref 1 Formaldehyde induces ferroptosis in hippocampal neuronal cells by upregulation of the Warburg effect. Toxicology. 2021 Jan 30;448:152650. doi: 10.1016/j.tox.2020.152650. Epub 2020 Nov 28.