Ferroptosis-centered Disease Response Information
General Information of the Disease (ID: DIS00154)
Name |
Bone marrow injury
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ICD |
ICD-11: PK81
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Full List of Target(s) of This Ferroptosis-centered Disease
Transferrin receptor protein 1 (TFRC)
In total 1 item(s) under this target | ||||
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target | [1] | |||
Target for Ferroptosis | Marker/Suppressor/Driver | |||
Responsed Disease | Bone marrow injury [ICD-11: PK81] | |||
Responsed Regulator | Fanconi anemia group D2 protein (FANCD2) | Suppressor | ||
Pathway Response | Fatty acid metabolism | hsa01212 | ||
Ferroptosis | hsa04216 | |||
Cell Process | Cell ferroptosis | |||
In Vitro Model | mBMSCs (Mouse bone marrow stromal cells) | |||
Response regulation | Bone marrow injury remains a serious concern in traditional cancer treatment. FANCD2 regulated genes and/or expression of proteins involved in iron metabolism (e.g., FTH1, TF, TFRC, HAMP, HSPB1, SLC40A1, and STEAP3) and lipid peroxidation (e.g., GPX4). | |||
Heat shock protein beta-1 (HSPB1)
In total 1 item(s) under this target | ||||
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target | [1] | |||
Target for Ferroptosis | Marker/Suppressor | |||
Responsed Disease | Bone marrow injury [ICD-11: PK81] | |||
Responsed Regulator | Fanconi anemia group D2 protein (FANCD2) | Suppressor | ||
Pathway Response | Fatty acid metabolism | hsa01212 | ||
Ferroptosis | hsa04216 | |||
Cell Process | Cell ferroptosis | |||
In Vitro Model | mBMSCs (Mouse bone marrow stromal cells) | |||
Response regulation | Bone marrow injury remains a serious concern in traditional cancer treatment. FANCD2 regulated genes and/or expression of proteins involved in iron metabolism (e.g., FTH1, TF, TFRC, HAMP, HSPB1, SLC40A1, and STEAP3) and lipid peroxidation (e.g., GPX4). | |||
Ferritin heavy chain (FTH1)
In total 1 item(s) under this target | ||||
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target | [1] | |||
Target for Ferroptosis | Marker/Suppressor | |||
Responsed Disease | Bone marrow injury [ICD-11: PK81] | |||
Responsed Regulator | Fanconi anemia group D2 protein (FANCD2) | Suppressor | ||
Pathway Response | Fatty acid metabolism | hsa01212 | ||
Ferroptosis | hsa04216 | |||
Cell Process | Cell ferroptosis | |||
In Vitro Model | mBMSCs (Mouse bone marrow stromal cells) | |||
Response regulation | Bone marrow injury remains a serious concern in traditional cancer treatment. FANCD2 regulated genes and/or expression of proteins involved in iron metabolism (e.g., FTH1, TF, TFRC, HAMP, HSPB1, SLC40A1, and STEAP3) and lipid peroxidation (e.g., GPX4). | |||