Ferroptosis-centered Disease Response Information
General Information of the Disease (ID: DIS00143)
| Name |
Nerve injury
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| ICD |
ICD-11: NA04
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Full List of Target(s) of This Ferroptosis-centered Disease
Cystine/glutamate transporter (SLC7A11)
| In total 1 item(s) under this target | |||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target | [1] | ||||
| Target for Ferroptosis | Suppressor | ||||
| Responsed Disease | Nerve injury [ICD-11: NA04] | ||||
| Responsed Regulator | hsa-miR-378a-3p (miRNA) | Driver | |||
| Pathway Response | Glutathione metabolism | hsa00480 | |||
| Ferroptosis | hsa04216 | ||||
| Cell Process | Cell ferroptosis | ||||
| In Vitro Model | HT22 cells | Normal | Mus musculus | CVCL_0321 | |
| In Vivo Model |
All the animals were housed in a temperature- and humidity-controlled room under a 12 h light/dark cycle and maintained in standard cages with free access to food and water. After seven days of breeding, the mice were randomly assigned to four groups of fifteen animals each. The animals in the four groups were treated with Pb acetate indrinking waterat doses of 0, 250 mg/L, 500 mg/L, and 1000 mg/L (control, LPb, MPb, and HPb groups, respectively). The Pb exposure period was 12 weeks.
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| Response regulation | Inhibition of miR-378a-3p expression reversed the reduction in GSH and the increase in lipid ROS levels induced by lead exposure. MiR-378a-3p exerted an important effect by regulating SLC7A11 expression in nerve injury induced by lead exposure. | ||||