Ferroptosis-centered Disease Response Information
General Information of the Disease (ID: DIS00091)
| Name |
Presbycusis
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| ICD |
ICD-11: AB54
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Full List of Target(s) of This Ferroptosis-centered Disease
Iron-responsive element-binding protein 2 (IREB2)
| In total 1 item(s) under this target | |||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target | [1] | ||||
| Target for Ferroptosis | Driver | ||||
| Responsed Disease | Age-related hearing loss [ICD-11: AB54] | ||||
| Responsed Drug | D-Galactose | Phase 2 | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Ferroptosis | hsa04216 | ||||
| Apoptosis | hsa04210 | ||||
| Cell Process | Cell ferroptosis | ||||
| Cell apoptosis | |||||
| In Vitro Model | PC12 cells | Adrenal gland pheochromocytoma | Rattus norvegicus | CVCL_0481 | |
| In Vivo Model |
A total of 150 male Sprague-Dawley rats were obtained from the Experimental Animal Centre of Hubei Province. After deep anaesthesia, we placed each rat on an electric blanket to maintain its body temperature. We placed the positive electrode under the skin of the vertex, the negative electrode into the measured ear and the ground electrode into the other ear. We used a Tucker-Davis Technologies System (RZ6; Tucker-Davis Tech. Inc., Alachua, FL, USA) to record the responses of the rats to sounds of different frequencies as previously described.
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| Response regulation | The study measured iron levels in a simulated ageing model established by the addition of d-galactose (d-gal). These changes were accompanied by upregulation of iron regulatory protein 2 (IRP-2), which led to an increase in transferrin receptor 1 (TfR-1), thus increasing iron entry into cells and potentially leading to ferroptosis. Relieving ferroptosis might be a new intervention strategy for age-related hearing loss. | ||||