Ferroptosis-centered Disease Response Information

General Information of the Disease (ID: DIS00043)
Name
Testicular cancer
ICD
ICD-11: 2C80
Full List of Target(s) of This Ferroptosis-centered Disease
Cystine/glutamate transporter (SLC7A11)
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Testicular cancer [ICD-11: 2C80]
Responsed Regulator Coiled-coil domain-containing protein 6 (CCDC6) Driver
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model NTERA-2 cells Embryonal carcinoma Homo sapiens CVCL_0034
TM4 cells Normal Mus musculus CVCL_4327
MZ-GC-1 cells Gastric adenocarcinoma Homo sapiens CVCL_4U28
MZ-GC-2 cells Gastric adenocarcinoma Homo sapiens CVCL_4U29
Response regulation Testicular cancers are among the most common malignancies in young males. The loss of CCDC6 was associated with an enhancement of the xCT/SLC7A11 cystine antiporter expression which, by promoting the accumulation of ROS, interfered with the activation of ferroptosis pathway.
References
Ref 1 The tumour suppressor CCDC6 is involved in ROS tolerance and neoplastic transformation by evading ferroptosis. Heliyon. 2021 Nov 15;7(11):e08399. doi: 10.1016/j.heliyon.2021.e08399. eCollection 2021 Nov.