Ferroptosis-centered Disease Response Information

General Information of the Disease (ID: DIS00008)
Name
Central nervous system cancer
ICD
ICD-11: 2A02
Full List of Target(s) of This Ferroptosis-centered Disease
Nuclear factor erythroid 2-related factor 2 (NFE2L2)
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Target for Ferroptosis Marker/Suppressor
Responsed Disease CNS diseases [ICD-11: 2A02]
Responsed Drug Polygonatum cyrtonemaHua Polysaccharides Investigative
 Drug Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell apoptosis
In Vitro Model BV-2 cells Normal Mus musculus CVCL_0182
Response regulation Subsequent studies have revealed that Polygonatum cyrtonemaHua Polysaccharides (PCP) alleviates ferroptosis in microglia due to protein levels of ERASTIN/RSL3 inhibitor SLC7A11/GPX4 by activating the NRF2/HO-1 signaling pathway. PCP has the development potential as a new drug candidate for treating CNS diseases.
Heme oxygenase 1 (HMOX1)
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease CNS diseases [ICD-11: 2A02]
Responsed Drug Polygonatum cyrtonemaHua Polysaccharides Investigative
 Drug Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell apoptosis
In Vitro Model BV-2 cells Normal Mus musculus CVCL_0182
Response regulation Subsequent studies have revealed that Polygonatum cyrtonemaHua Polysaccharides (PCP) alleviates ferroptosis in microglia due to protein levels of ERASTIN/RSL3 inhibitor SLC7A11/GPX4 by activating the NRF2/HO-1 signaling pathway. PCP has the development potential as a new drug candidate for treating CNS diseases.
References
Ref 1 Polygonatum cyrtonema Hua Polysaccharides Protect BV2 Microglia Relief Oxidative Stress and Ferroptosis by Regulating NRF2/HO-1 Pathway. Molecules. 2022 Oct 20;27(20):7088. doi: 10.3390/molecules27207088.