Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG60001)
Regulator Name RHEBP1 (Pseudogene)
Synonyms
Ras-Homolog Enriched In Brain Pseudogene 1; Ras Homolog Enriched In Brain 1; RHEB1
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Gene Name RHEBP1
Regulator Type Pseudogene
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
RHEBP1 can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Unspecific Target [Unspecific Target]
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Responsed Disease Acute kidney failure ICD-11: GB60
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Apoptosis hsa04210
Necroptosis hsa04217
Cell Process Cell ferroptosis
Cell apoptosis
Cell necroptosis
In Vitro Model
 mTECs (Mouse tubular epithelial cells)
In Vivo Model
Homozygous Rheb1 floxed mice (C57BL/6J background) were kindly provided by Dr. Xiao. To induce AKI in mice, Tubule-Rheb1-/-, Tubule-Tsc1+/- and their control littermates aged between 8 and 10 weeks were injected with a single dose of 20 mg/kg cisplatin (cat: P4394, Sigma-Aldrich, St. Louis, MO) intraperitoneally. Mice were sacrificed at day 1, 2 and 3 after cisplatin administration, and mice in AKI models died before being sacrificed were excluded.

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Response regulation Rheb1 alleviates cisplatin-induced acute kidney injury (AKI) via maintaining mitochondrial homeostasis. Activation of Rheb1 may provide a new therapeutic strategy for AKI.
Acute kidney failure [ICD-11: GB60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator RHEBP1 (Pseudogene) Pseudogene
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Apoptosis hsa04210
Necroptosis hsa04217
Cell Process Cell ferroptosis
Cell apoptosis
Cell necroptosis
In Vitro Model
 mTECs (Mouse tubular epithelial cells)
In Vivo Model
Homozygous Rheb1 floxed mice (C57BL/6J background) were kindly provided by Dr. Xiao. To induce AKI in mice, Tubule-Rheb1-/-, Tubule-Tsc1+/- and their control littermates aged between 8 and 10 weeks were injected with a single dose of 20 mg/kg cisplatin (cat: P4394, Sigma-Aldrich, St. Louis, MO) intraperitoneally. Mice were sacrificed at day 1, 2 and 3 after cisplatin administration, and mice in AKI models died before being sacrificed were excluded.

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Response regulation Rheb1 alleviates cisplatin-induced acute kidney injury (AKI) via maintaining mitochondrial homeostasis. Activation of Rheb1 may provide a new therapeutic strategy for AKI.
References
Ref 1 Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis. Cell Death Dis. 2020 May 13;11(5):364. doi: 10.1038/s41419-020-2539-4.