Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG40043)
Regulator Name Circ_0000745 (circRNA)
Synonyms
Circ_0000745
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Gene Name Circ_0000745
Regulator Type circRNA
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
Circ_0000745 can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Unspecific Target [Unspecific Target]
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Responsed Disease Myeloid leukaemia ICD-11: 2B33
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Gluconeogenesis hsa00010
Apoptosis hsa04210
Cell Process Cell ferroptosis
Cell proliferation
Cell apoptosis
In Vitro Model
 Kasumi-1 cells Acute myeloid leukemia Homo sapiens CVCL_0589
KG-1 cells Adult acute myeloid leukemia Homo sapiens CVCL_0374
Response regulation Circ_0000745 promoted cell cycle progression and glycolytic metabolism and inhibited the apoptosis and ferroptosis of acute lymphoblastic leukemia cells by regulating miR-494-3p/NET1 axis. Circ_0000745/miR-494-3p/NET1 axis may provide novel potential targets for the diagnosis and treatment of acute lymphoblastic leukemia (ALL).
Myeloid leukaemia [ICD-11: 2B33]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator Circ_0000745 (circRNA) circRNA
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Gluconeogenesis hsa00010
Apoptosis hsa04210
Cell Process Cell ferroptosis
Cell proliferation
Cell apoptosis
In Vitro Model
 Kasumi-1 cells Acute myeloid leukemia Homo sapiens CVCL_0589
KG-1 cells Adult acute myeloid leukemia Homo sapiens CVCL_0374
Response regulation Circ_0000745 promoted cell cycle progression and glycolytic metabolism and inhibited the apoptosis and ferroptosis of acute lymphoblastic leukemia cells by regulating miR-494-3p/NET1 axis. Circ_0000745/miR-494-3p/NET1 axis may provide novel potential targets for the diagnosis and treatment of acute lymphoblastic leukemia (ALL).
References
Ref 1 Circ_0000745 promotes acute lymphoblastic leukemia progression through mediating miR-494-3p/NET1 axis. Hematology. 2022 Dec;27(1):11-22. doi: 10.1080/16078454.2021.2008590.