Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG40033)
Regulator Name CircST6GALNAC6 (circRNA)
Synonyms
CircST6GALNAC6
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Gene Name CircST6GALNAC6
Regulator Type circRNA
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
CircST6GALNAC6 can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Heat shock protein beta-1 (HSPB1) [Suppressor; Marker]
 Target Info 
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Target for Ferroptosis Marker/Suppressor
Responsed Disease Bladder cancer ICD-11: 2C94
 Disease Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 UM-UC-3 cells Bladder carcinoma Homo sapiens CVCL_1783
J82 cells Bladder carcinoma Homo sapiens CVCL_0359
Response regulation CircST6GALNAC6 inhibits HSPB1 and promotes cell ferroptosis by occupying the phosphorylation site (Ser-15) of HSBP1 and activating the P38 MAPK signaling pathway. Therefore, enhancing the expression of circST6GALNAC6 to promote ferroptosis or using circST6GALNAC6 as a biomarker of ferroptosis sensitivity is of considerable importance to the development and application of ferroptosis intervention methods in bladder cancer.
Bladder cancer [ICD-11: 2C94]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator CircST6GALNAC6 (circRNA) circRNA
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 UM-UC-3 cells Bladder carcinoma Homo sapiens CVCL_1783
J82 cells Bladder carcinoma Homo sapiens CVCL_0359
Response regulation CircST6GALNAC6 inhibits HSPB1 and promotes cell ferroptosis by occupying the phosphorylation site (Ser-15) of HSBP1 and activating the P38 MAPK signaling pathway. Therefore, enhancing the expression of circST6GALNAC6 to promote ferroptosis or using circST6GALNAC6 as a biomarker of ferroptosis sensitivity is of considerable importance to the development and application of ferroptosis intervention methods in bladder cancer.
References
Ref 1 CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis. Lab Invest. 2022 Dec;102(12):1323-1334. doi: 10.1038/s41374-022-00826-3. Epub 2022 Aug 9.