Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG30060)
Regulator Name LINC00472 (IncRNA)
Synonyms
C6ORF155; DJ288M22.3; FLJ13189; P53RRA
    Click to Show/Hide
Gene Name LINC00472
Gene ID 79940
Regulator Type lncRNA
Ensembl ID ENSG00000233237
HGNC ID
HGNC:21380
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
LINC00472 can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
Browse Target
Browse Disease
Unspecific Target [Unspecific Target]
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Responsed Disease Lung cancer ICD-11: 2C25
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Apoptosis hsa04210
Cell Process Cell ferroptosis
Cell apoptosis
Cell proliferation
In Vitro Model
 A-549 cells Lung adenocarcinoma Homo sapiens CVCL_0023
SPC-A1 cells Endocervical adenocarcinoma Homo sapiens CVCL_6955
NCI-H522 cells Non-small cell lung carcinoma Homo sapiens CVCL_1567
HBE1 cells Normal Homo sapiens CVCL_0287
NCI-H1299 cells Lung large cell carcinoma Homo sapiens CVCL_0060
MRC-5 cells Normal Homo sapiens CVCL_0440
NCI-H358 cells Minimally invasive lung adenocarcinoma Homo sapiens CVCL_1559
PC-9 cells Lung adenocarcinoma Homo sapiens CVCL_B260
95C cells Lung giant cell carcinoma Homo sapiens CVCL_7109
95D cells Lung giant cell carcinoma Homo sapiens CVCL_7110
In Vivo Model
SCID mice (Hunan SJA Laboratory Animal Co. Ltd.) were injected with the indicated cells in the mammary fat pad (10 mice/group). Injected mice were imaged from both the dorsal and ventral sides every three days.

    Click to Show/Hide
Response regulation P53RRA bound Ras GTPase-activating protein-binding protein 1 (G3BP1) using nucleotides 1 and 871 of P53RRA and the RRM interaction domain of G3BP1 (aa 177-466). The cytosolic P53RRA-G3BP1 interaction displaced p53 from a G3BP1 complex, resulting in greater p53 retention in the nucleus, which led to cell-cycle arrest, apoptosis, and ferroptosis in lung cancer cell lines.
Lung cancer [ICD-11: 2C25]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator LINC00472 (IncRNA) lncRNA
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Apoptosis hsa04210
Cell Process Cell ferroptosis
Cell apoptosis
Cell proliferation
In Vitro Model
 A-549 cells Lung adenocarcinoma Homo sapiens CVCL_0023
SPC-A1 cells Endocervical adenocarcinoma Homo sapiens CVCL_6955
NCI-H522 cells Non-small cell lung carcinoma Homo sapiens CVCL_1567
HBE1 cells Normal Homo sapiens CVCL_0287
NCI-H1299 cells Lung large cell carcinoma Homo sapiens CVCL_0060
MRC-5 cells Normal Homo sapiens CVCL_0440
NCI-H358 cells Minimally invasive lung adenocarcinoma Homo sapiens CVCL_1559
PC-9 cells Lung adenocarcinoma Homo sapiens CVCL_B260
95C cells Lung giant cell carcinoma Homo sapiens CVCL_7109
95D cells Lung giant cell carcinoma Homo sapiens CVCL_7110
In Vivo Model
SCID mice (Hunan SJA Laboratory Animal Co. Ltd.) were injected with the indicated cells in the mammary fat pad (10 mice/group). Injected mice were imaged from both the dorsal and ventral sides every three days.

    Click to Show/Hide
Response regulation P53RRA bound Ras GTPase-activating protein-binding protein 1 (G3BP1) using nucleotides 1 and 871 of P53RRA and the RRM interaction domain of G3BP1 (aa 177-466). The cytosolic P53RRA-G3BP1 interaction displaced p53 from a G3BP1 complex, resulting in greater p53 retention in the nucleus, which led to cell-cycle arrest, apoptosis, and ferroptosis in lung cancer cell lines.
References
Ref 1 A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53. Cancer Res. 2018 Jul 1;78(13):3484-3496. doi: 10.1158/0008-5472.CAN-17-3454. Epub 2018 Mar 27.