Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG20107)
Regulator Name hsa-let-7b-5p (miRNA)
Synonyms
hsa-let-7b-5p
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Gene Name hsa-let-7b-5p
Regulator Type miRNA
MiRBase ID MIMAT0000063
Sequence
UGAGGUAGUAGGUUGUGUGGUU

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Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
hsa-let-7b-5p can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Unspecific Target [Unspecific Target]
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Responsed Disease Acute myeloid leukaemia ICD-11: 2A60
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell proliferation
Cell migration
Cell invasion
In Vitro Model
 hBMSCs (Bone marrow stromal cells)
K-562 cells Chronic myelogenous leukemia Homo sapiens CVCL_0004
THP-1 cells Childhood acute monocytic leukemia Homo sapiens CVCL_0006
HL-60 cells Adult acute myeloid leukemia Homo sapiens CVCL_0002
MOLM-13 cells Adult acute myeloid leukemia Homo sapiens CVCL_2119
In Vivo Model
All BALB/C male nude mice (6 weeks old), purchased from Beijing Weitong lihua Experimental Animal Technology Co., Ltd, were maintained in pathogen-free facilities. The K562 or HL-60 cells (3 x 106, 200 ul) transfected with circKDM4C, vector, si-NC, or si-circKDM4C were subcutaneously injected into the right flank of nude mice (9 mice each group) for tumorigenesis. The maximum (Length) and minimum (Width) length of the tumors were measured.

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Response regulation The overexpression of circKDM4C in acute myeloid leukemia (AML) cell lines inhibited the cell proliferation, migration, invasion, and promoted ferroptosis. The expression of circKDM4C and hsa-let-7b-5p are negatively correlated, while circKDM4C and p53 are positively correlated to AML patients. Moreover, circKDM4C induces ferroptosis by sponging hsa-let-7b-5p which upregulates the expression of P53.
Acute myeloid leukaemia [ICD-11: 2A60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator hsa-let-7b-5p (miRNA) miRNA
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell proliferation
Cell migration
Cell invasion
In Vitro Model
 hBMSCs (Bone marrow stromal cells)
K-562 cells Chronic myelogenous leukemia Homo sapiens CVCL_0004
THP-1 cells Childhood acute monocytic leukemia Homo sapiens CVCL_0006
HL-60 cells Adult acute myeloid leukemia Homo sapiens CVCL_0002
MOLM-13 cells Adult acute myeloid leukemia Homo sapiens CVCL_2119
In Vivo Model
All BALB/C male nude mice (6 weeks old), purchased from Beijing Weitong lihua Experimental Animal Technology Co., Ltd, were maintained in pathogen-free facilities. The K562 or HL-60 cells (3 x 106, 200 ul) transfected with circKDM4C, vector, si-NC, or si-circKDM4C were subcutaneously injected into the right flank of nude mice (9 mice each group) for tumorigenesis. The maximum (Length) and minimum (Width) length of the tumors were measured.

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Response regulation The overexpression of circKDM4C in acute myeloid leukemia (AML) cell lines inhibited the cell proliferation, migration, invasion, and promoted ferroptosis. The expression of circKDM4C and hsa-let-7b-5p are negatively correlated, while circKDM4C and p53 are positively correlated to AML patients. Moreover, circKDM4C induces ferroptosis by sponging hsa-let-7b-5p which upregulates the expression of P53.
References
Ref 1 CircKDM4C upregulates P53 by sponging hsa-let-7b-5p to induce ferroptosis in acute myeloid leukemia. Environ Toxicol. 2021 Jul;36(7):1288-1302. doi: 10.1002/tox.23126. Epub 2021 Mar 18.