Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG20102)
Regulator Name rno-miR-199a-5p (miRNA)
Synonyms
rno-miR-199a-5p
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Gene Name rno-miR-199a-5p
Regulator Type miRNA
MiRBase ID MIMAT0000872
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
rno-miR-199a-5p can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Unspecific Target [Unspecific Target]
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Responsed Disease Ischemia/reperfusion injury ICD-11: DB98
 Disease Info 
Pathway Response Ferroptosis hsa04216
PI3K-Akt signaling pathway hsa04151
Cell Process Cell ferroptosis
In Vitro Model
 CHO-S/H9C2 cells Normal Cricetulus griseus CVCL_A0TS
Response regulation miR-199a-5 promotes ferroptosis-induced cardiomyocyte death via the inhibition of AKT/eNOS signaling pathway, thereby contributing to OGD/R injury, suggesting its potential as a target for the development of myocardial ischemia/reperfusion (I/R) injury and focusing on inhibition of miR-199a-5 may be beneficial for attenuating myocardial I/R injury.
Ischemia/reperfusion injury [ICD-11: DB98]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator rno-miR-199a-5p (miRNA) miRNA
 Regulator Info 
Pathway Response Ferroptosis hsa04216
PI3K-Akt signaling pathway hsa04151
Cell Process Cell ferroptosis
In Vitro Model
 CHO-S/H9C2 cells Normal Cricetulus griseus CVCL_A0TS
Response regulation miR-199a-5 promotes ferroptosis-induced cardiomyocyte death via the inhibition of AKT/eNOS signaling pathway, thereby contributing to OGD/R injury, suggesting its potential as a target for the development of myocardial ischemia/reperfusion (I/R) injury and focusing on inhibition of miR-199a-5 may be beneficial for attenuating myocardial I/R injury.
References
Ref 1 MiR-199a-5p promotes ferroptosis-induced cardiomyocyte death responding to oxygen-glucose deprivation/reperfusion injury via inhibiting Akt/eNOS signaling pathway. Kaohsiung J Med Sci. 2022 Nov;38(11):1093-1102. doi: 10.1002/kjm2.12605. Epub 2022 Oct 18.