Ferroptosis Regulator Information
General Information of the Ferroptosis Regulator (ID: REG10375)
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
MPC1
can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Unspecific Target [Unspecific Target]
| In total 1 item(s) under this target | |||||
| Experiment 1 Reporting the Ferroptosis Target of This Regulator | [1] | ||||
| Responsed Disease | Head neck squamous cell carcinoma | ICD-11: 2D60 | |||
| Pathway Response | Glutamate metabolism | hsa00250 | |||
| Ferroptosis | hsa04216 | ||||
| Cell Process | Cell ferroptosis | ||||
| Cell proliferation | |||||
| Cell migration | |||||
In Vitro Model |
NH-3 cells | Tongue squamous cell carcinoma | Homo sapiens | CVCL_8126 | |
| HN4 cells | Clear cell renal cell carcinoma | Homo sapiens | CVCL_IS30 | ||
| In Vivo Model |
Six-week-old athymic BALB/c male nude mice (nu/nu) were purchased from OrientBio (Seoul, Republic of Korea). HN4 parental cells with transfection of vector control or shGPX4 were subcutaneously injected into the bilateral flank of nude mice. The same was performed in HN4 erPCC with transfection of control vector or shGPX4. Each group included six mice. In other experiments, HN4 parental cells with transfection of control vector or shMPC1 were injected to nude mice in the same way above. HN4 parental cells and erPCC without target gene silencing were also injected into nude mice. Each group included six mice. From the day when gross nodules were detected in tumor implants, mice were subjected to different treatments: vehicle or sulfasalazine (250 mg/kg daily per intraperitoneal route).
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| Response regulation | The regulation of a KDM5A- MPC1 axis contributes to promoting ferroptosis susceptibility in head and neck cancer (HNC) cells, which might be recommended as a promising combination therapy in combating drug-tolerant persister cancer cells. | ||||
Head neck squamous cell carcinoma [ICD-11: 2D60]
| In total 1 item(s) under this disease | |||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response | [1] | ||||
| Target Regulator | Mitochondrial pyruvate carrier 1 (MPC1) | Protein coding | |||
| Pathway Response | Glutamate metabolism | hsa00250 | |||
| Ferroptosis | hsa04216 | ||||
| Cell Process | Cell ferroptosis | ||||
| Cell proliferation | |||||
| Cell migration | |||||
In Vitro Model |
NH-3 cells | Tongue squamous cell carcinoma | Homo sapiens | CVCL_8126 | |
| HN4 cells | Clear cell renal cell carcinoma | Homo sapiens | CVCL_IS30 | ||
| In Vivo Model |
Six-week-old athymic BALB/c male nude mice (nu/nu) were purchased from OrientBio (Seoul, Republic of Korea). HN4 parental cells with transfection of vector control or shGPX4 were subcutaneously injected into the bilateral flank of nude mice. The same was performed in HN4 erPCC with transfection of control vector or shGPX4. Each group included six mice. In other experiments, HN4 parental cells with transfection of control vector or shMPC1 were injected to nude mice in the same way above. HN4 parental cells and erPCC without target gene silencing were also injected into nude mice. Each group included six mice. From the day when gross nodules were detected in tumor implants, mice were subjected to different treatments: vehicle or sulfasalazine (250 mg/kg daily per intraperitoneal route).
Click to Show/Hide
|
||||
| Response regulation | The regulation of a KDM5A- MPC1 axis contributes to promoting ferroptosis susceptibility in head and neck cancer (HNC) cells, which might be recommended as a promising combination therapy in combating drug-tolerant persister cancer cells. | ||||