Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG10297)
Regulator Name PHD finger protein 21A (PHF21A)
Synonyms
BHC80, KIAA1696; BHC80a; BRAF35-HDAC complex protein BHC80
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Gene Name PHF21A
Gene ID 51317
Regulator Type Protein coding
Uniprot ID Q96BD5
Sequence
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRK
NLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQQYHHHHAQQSAAASPNLTASQ
KTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNL
QTSSKVTGPGAEAVQIVAKNTVTLVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVA
QNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQNSIHPVRVVNGQTATIAKTFPM
AQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTITPPAAPKPKRE
ENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNST
MHPGTRKRGRPPKYNAVLGFGALTPTSPQSSHPDSPENEKTETTFTFPAPVQPVSLPSPT
STDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKE
EAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKQLSNSISKCMEM
KNTILARQKEMHSSLEKVKQLIRLIHGIDLSKPVDSEATVGAISNGPDCTPPANAATSTP
APSPSSQSCTANCNQGEETK

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Function
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.

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HGNC ID
HGNC:24156
KEGG ID hsa:51317
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
PHF21A can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Browse Disease
Unspecific Target [Unspecific Target]
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Responsed Disease Ovarian dysfunction ICD-11: 5A80
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 hOGCs (Human ovarian granulosa cells)
Response regulation The study identified five ferroptosis-related genes (NOX1, ACVR1B, PHF21A, FTL, and GALNT14) that may be involved in the pathogenesis of polycystic ovary syndrome (PCOS), which may provide a novel perspective for the clinical diagnosis and treatment of PCOS.
Ovarian dysfunction [ICD-11: 5A80]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator PHD finger protein 21A (PHF21A) Protein coding
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model
 hOGCs (Human ovarian granulosa cells)
Response regulation The study identified five ferroptosis-related genes (NOX1, ACVR1B, PHF21A, FTL, and GALNT14) that may be involved in the pathogenesis of polycystic ovary syndrome (PCOS), which may provide a novel perspective for the clinical diagnosis and treatment of PCOS.
References
Ref 1 Relationships of ferroptosis-related genes with the pathogenesis in polycystic ovary syndrome. Front Med (Lausanne). 2023 Feb 17;10:1120693. doi: 10.3389/fmed.2023.1120693. eCollection 2023.