Ferroptosis Regulator Information
General Information of the Ferroptosis Regulator (ID: REG10228)
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
FXN
can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Unspecific Target [Unspecific Target]
In total 1 item(s) under this target | ||||
Experiment 1 Reporting the Ferroptosis Target of This Regulator | [1] | |||
Responsed Disease | Diabetes mellitus | ICD-11: 5A10 | ||
Pathway Response | Fatty acid metabolism | hsa01212 | ||
Ferroptosis | hsa04216 | |||
Cell Process | Cell ferroptosis | |||
In Vitro Model |
INS-1 cells | Insulinoma | Rattus norvegicus | CVCL_0352 |
Response regulation | FXN, amitochondrial proteininvolved iniron metabolismandROSregulation, was shown by other studies reduced in diabetic islets than nondiabetic and impaired insulin secretion after disruption in mice pancreatic -cells. | |||
Diabetes mellitus [ICD-11: 5A10]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the Ferroptosis-centered Disease Response | [1] | |||
Target Regulator | Frataxin, mitochondrial (FXN) | Protein coding | ||
Pathway Response | Fatty acid metabolism | hsa01212 | ||
Ferroptosis | hsa04216 | |||
Cell Process | Cell ferroptosis | |||
In Vitro Model |
INS-1 cells | Insulinoma | Rattus norvegicus | CVCL_0352 |
Response regulation | FXN, amitochondrial proteininvolved iniron metabolismandROSregulation, was shown by other studies reduced in diabetic islets than nondiabetic and impaired insulin secretion after disruption in mice pancreatic -cells. | |||