Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG10045)
Regulator Name Citrate synthase, mitochondrial (CS)
Synonyms
Citrate (Si)-synthase
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Gene Name CS
Gene ID 1431
Regulator Type Protein coding
Uniprot ID O75390
Sequence
MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVV
GQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLF
WLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESN
FARAYAQGISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNF
TNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPL
HGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQ
REFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYY
TVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG

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Family Citrate synthase family
HGNC ID
HGNC:2422
KEGG ID hsa:1431
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
CS can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Unspecific Target [Unspecific Target]
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Responsed Disease Fibrosarcoma ICD-11: 2B53
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model
 HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
Calu-1 cells Lung squamous cell carcinoma Homo sapiens CVCL_0608
U2OS cells Osteosarcoma Homo sapiens CVCL_0042
HEK-293T cells Normal Homo sapiens CVCL_0063
mEFs (Mouse embryonic fibroblasts)
BJeH (Human foreskin fibroblasts)
BJeHLT (Human foreskin fibroblasts)
BJeLR (Human foreskin fibroblasts)
TC-32 cells Primitive neuroectodermal tumor Homo sapiens CVCL_7151
Sk-ES-1 cells Ewing sarcoma Homo sapiens CVCL_0627
Response regulation The study identified specific roles for RPL8, IREB2, ATP5G3, TTC35, CS and ACSF2 in erastin-induced ferroptosis. A plausible new hypothesis to emerge from these data is that CS and ACSF2 are required to synthesize a specific lipid precursor necessary for death in fibrosarcoma HT1080 cells.
Fibrosarcoma [ICD-11: 2B53]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator Citrate synthase, mitochondrial (CS) Protein coding
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model
 HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
Calu-1 cells Lung squamous cell carcinoma Homo sapiens CVCL_0608
U2OS cells Osteosarcoma Homo sapiens CVCL_0042
HEK-293T cells Normal Homo sapiens CVCL_0063
mEFs (Mouse embryonic fibroblasts)
BJeH (Human foreskin fibroblasts)
BJeHLT (Human foreskin fibroblasts)
BJeLR (Human foreskin fibroblasts)
TC-32 cells Primitive neuroectodermal tumor Homo sapiens CVCL_7151
Sk-ES-1 cells Ewing sarcoma Homo sapiens CVCL_0627
Response regulation The study identified specific roles for RPL8, IREB2, ATP5G3, TTC35, CS and ACSF2 in erastin-induced ferroptosis. A plausible new hypothesis to emerge from these data is that CS and ACSF2 are required to synthesize a specific lipid precursor necessary for death in fibrosarcoma HT1080 cells.
References
Ref 1 Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012 May 25;149(5):1060-72. doi: 10.1016/j.cell.2012.03.042.